Pharmacogenomics of the natriuretic peptide system in heart failure
A Abuzaanona, D Lanfear - Current heart failure reports, 2017 - Springer
Abstract Purpose of Review Heart failure (HF) continues to be a public health burden
despite advances in therapy, and the natriuretic peptide (NP) system is clearly of critical …
despite advances in therapy, and the natriuretic peptide (NP) system is clearly of critical …
[HTML][HTML] MutPred Splice: machine learning-based prediction of exonic variants that disrupt splicing
We have developed a novel machine-learning approach, MutPred Splice, for the
identification of coding region substitutions that disrupt pre-mRNA splicing. Applying …
identification of coding region substitutions that disrupt pre-mRNA splicing. Applying …
[HTML][HTML] Differential transcriptional responses to Ebola and Marburg virus infection in bat and human cells
The unprecedented outbreak of Ebola in West Africa resulted in over 28,000 cases and
11,000 deaths, underlining the need for a better understanding of the biology of this highly …
11,000 deaths, underlining the need for a better understanding of the biology of this highly …
Recent advances in the genetics of hypertension
Hypertension is a silent killer worldwide, caused by both genetic and environmental factors.
Until now, genetic and genomic association studies of hypertension are reporting different …
Until now, genetic and genomic association studies of hypertension are reporting different …
NPR3 protects cardiomyocytes from apoptosis through inhibition of cytosolic BRCA1 and TNF-α
ABSTRACT Natriuretic peptide receptor 3 (NPR3) is a clearance receptor by binding and
internalizing natriuretic peptides (NPs) for ultimate degradation. Patients with cardiac failure …
internalizing natriuretic peptides (NPs) for ultimate degradation. Patients with cardiac failure …
Circulating atrial natriuretic peptide genetic association study identifies a novel gene cluster associated with stroke in whites
NL Pereira, N Tosakulwong, CG Scott… - Circulation …, 2015 - Am Heart Assoc
Background—The goal of this study was to identify genetic determinants of plasma N-
terminal proatrial natriuretic peptide (NT-proANP) in the general community by performing a …
terminal proatrial natriuretic peptide (NT-proANP) in the general community by performing a …
[HTML][HTML] RNA-Seq data analysis reveals novel nonsense mutations in the NPR3 gene leading to the progression of intellectual disability disorder
P Garg, F Jamal, P Srivastava - Heliyon, 2024 - cell.com
Intellectual disability (ID) is a progressive disorder that affects around 1–3% of the world's
population. The heterogeneity of intellectual disability makes it difficult to diagnose as a …
population. The heterogeneity of intellectual disability makes it difficult to diagnose as a …
Genetic and nongenetic factors influencing pharmacokinetics of B-type natriuretic peptide
DE Lanfear, S Chow, B Padhukasahasram, J Li… - Journal of cardiac …, 2014 - Elsevier
Abstract Background Natriuretic peptides (NPs) represent a critical pathway in heart failure
(HF). However, there is wide individual variability in NP system activity, which could be partly …
(HF). However, there is wide individual variability in NP system activity, which could be partly …
[HTML][HTML] Epigenetic and transcriptional regulation of the human angiotensinogen gene by high salt
S Perla, A Kumar - bioRxiv, 2023 - ncbi.nlm.nih.gov
Hypertension is caused by a combination of genetic and environmental factors.
Angiotensinogen (AGT) is a component of RAAS, that regulates blood pressure. The human …
Angiotensinogen (AGT) is a component of RAAS, that regulates blood pressure. The human …
[HTML][HTML] A functional genetic variant (N521D) in natriuretic peptide receptor 3 is associated with diastolic dysfunction: the prevalence of asymptomatic ventricular …
NL Pereira, MM Redfield, C Scott, N Tosakulwong… - PloS one, 2014 - journals.plos.org
Objectives To evaluate the impact of a functional genetic variant in the natriuretic peptide
clearance receptor, NPR3, on circulating natriuretic peptides (NPs) and myocardial structure …
clearance receptor, NPR3, on circulating natriuretic peptides (NPs) and myocardial structure …