[HTML][HTML] Deep exome sequencing identifies enrichment of deleterious mosaic variants in neurodevelopmental disorder genes and mitochondrial tRNA regions in …
M Nishioka, J Takayama, N Sakai, A Kazuno… - Molecular …, 2023 - nature.com
Bipolar disorder (BD) is a global medical issue, afflicting around 1% of the population with
manic and depressive episodes. Despite various genetic studies, the genetic architecture …
manic and depressive episodes. Despite various genetic studies, the genetic architecture …
[HTML][HTML] Differences between bipolar disorder types 1 and 2 support the DSM two-syndrome concept
L Tondo, A Miola, M Pinna, M Contu… - International Journal of …, 2022 - Springer
Objective To compare characteristics of bipolar disorder patients diagnosed as DSM-5 types
I (BD-1) vs. II (BD-2). Methods We compared descriptive, psychopathological, and treatment …
I (BD-1) vs. II (BD-2). Methods We compared descriptive, psychopathological, and treatment …
Multi-omics data integration methods and their applications in psychiatric disorders
To study mental illness and health, in the past researchers have often broken down their
complexity into individual subsystems (eg, genomics, transcriptomics, proteomics, clinical …
complexity into individual subsystems (eg, genomics, transcriptomics, proteomics, clinical …
Diagnosis and management of bipolar disorders
FS Goes - bmj, 2023 - bmj.com
Bipolar disorders (BDs) are recurrent and sometimes chronic disorders of mood that affect
around 2% of the world's population and encompass a spectrum between severe elevated …
around 2% of the world's population and encompass a spectrum between severe elevated …
[HTML][HTML] Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease
J Lake, C Warly Solsberg, JJ Kim, J Acosta-Uribe… - Molecular …, 2023 - nature.com
Genome-wide association studies (GWAS) of Alzheimer's disease are predominantly carried
out in European ancestry individuals despite the known variation in genetic architecture and …
out in European ancestry individuals despite the known variation in genetic architecture and …
[HTML][HTML] Schizophrenia genomics: convergence on synaptic development, adult synaptic plasticity, or both?
J Hall, NJ Bray - Biological Psychiatry, 2022 - Elsevier
Large-scale genomic studies of schizophrenia have identified hundreds of genetic loci
conferring risk to the disorder. This progress offers an important route toward defining the …
conferring risk to the disorder. This progress offers an important route toward defining the …
[PDF][PDF] The HUNT Study: a population-based cohort for genetic research
BM Brumpton, S Graham, I Surakka, AH Skogholt… - Cell Genomics, 2022 - cell.com
Summary The Trøndelag Health Study (HUNT) is a population-based cohort of∼ 229,000
individuals recruited in four waves beginning in 1984 in Trøndelag County, Norway …
individuals recruited in four waves beginning in 1984 in Trøndelag County, Norway …
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains
Attention deficit hyperactivity disorder (ADHD) is a prevalent childhood psychiatric disorder,
with a major genetic component. Here we present a GWAS meta-analysis of ADHD …
with a major genetic component. Here we present a GWAS meta-analysis of ADHD …
[HTML][HTML] GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice
H Yamamoto, HC Lee-Okada, M Ikeda… - Molecular …, 2023 - nature.com
Large-scale genome-wide association studies (GWASs) on bipolar disorder (BD) have
implicated the involvement of the fatty acid desaturase (FADS) locus. These enzymes …
implicated the involvement of the fatty acid desaturase (FADS) locus. These enzymes …