Educational attainment (EduYears), a heritable trait often used as a proxy for cognitive
ability, is associated with various health and social outcomes. Previous genome-wide …

Inhibition of Glycogen synthase kinase 3 (GSK3) is a popular explanation for the effects of
lithium ions on mood regulation in bipolar disorder and other mental illnesses, including …

Genetic research in Autism Spectrum Disorder (ASD) has progressed tremendously in
recent decades. Dozens of genetic loci and hundreds of alterations in the genetic sequence …

There is a gap in knowledge regarding the polygenic underpinnings of brain anomalies
observed in youth bipolar disorder (BD). This study examined the association of a polygenic …

Genetic and environmental factors contribute to the etiology of Attention Deficit-Hyperactivity
Disorder (ADHD). In this sense, the study of epigenetic mechanisms could contribute to the …

Suicide is a multifaceted and poorly understood clinical outcome, and there is an urgent
need to advance research on its phenomenology and etiology. Epidemiological studies …

Moving in synchrony to the beat is a fundamental component of musicality. Here we
conducted a genome-wide association study to identify common genetic variants associated …

Abstract Machine learning (ML) holds promise for precision psychiatry, but its predictive
performance is unclear. We assessed whether ML provided added value over logistic …

Introduction Treatment of severe mental illness (SMI) symptoms, especially negative
symptoms and cognitive dysfunction in schizophrenia, remains a major unmet need. There …

Methods integrating genetics with transcriptomic reference panels prioritize risk genes and
mechanisms at only a fraction of trait-associated genetic loci, due in part to an overreliance …