Genetic risks for schizophrenia are theoretically mediated by genetic effects on brain
structure but it has been unclear which genes are associated with both schizophrenia and …

Improved understanding of the shared genetic architecture between psychiatric disorders
and brain white matter may provide mechanistic insights for observed phenotypic …

Background Mental disorders are among the top causes of disease burden worldwide.
Existing evidence regarding the repurposing of antihypertensives for mental disorders …

Regardless of which of the mechanisms described here plays a primary or secondary role in
the pathophysiology of bipolar disorder, all of these interact to worsen clinical outcomes for …

In the second half of the twentieth century, twin and family studies established beyond a
reasonable doubt that all forms of psychopathology are substantially heritable and highly …

Background Caffeine exposure modifies the turnover of monoamine neurotransmitters,
which play a role in several neuropsychiatric disorders. We conducted a Mendelian …

Bipolar disorder (BD) is a chronic mood disorder characterized by manic and depressive
episodes. Dysregulation of neuroplasticity and calcium homeostasis are frequently observed …

Nucleotide changes in gene regulatory elements are important determinants of neuronal
development and disease. Using massively parallel reporter assays in primary human cells …

Bipolar affective disorder (BPAD) are life-long disorders that account for significant morbidity
in afflicted patients. The etiology of BPAD is complex, combining genetic and environmental …

Bipolar disorder (BD) and obesity are highly comorbid. We previously performed a genome-
wide association study (GWAS) for BD risk accounting for the effect of body mass index …