Children who experience adversities have an elevated risk of mental health problems.
However, the extent to which adverse childhood experiences (ACEs) cause mental health …

Human brains vary across people and over time; such variation is not yet understood in
cellular terms. Here we describe a relationship between people's cortical neurons and …

Aim Symptoms of bipolar disorder (BD) include changes in mood, activity, energy, sleep,
and appetite. Since many of these processes are regulated by circadian function, circadian …

The question of how same-gene mutations can drive both cancer and neurodevelopmental
disorders has been puzzling. It has also been puzzling why those with neurodevelopmental …

Our earlier work has shown that genomic risk for schizophrenia converges with early life
complications in affecting risk for the disorder and sex-biased neurodevelopmental …

Genetic variants are traditionally known to shape the susceptibility to neuropsychiatric
disorders. An increasing number of studies indicate that remodeling of the gut microbiome …

The folding of the human cerebral cortex is a highly genetically regulated process that
allows for a much larger surface area to fit into the cranial vault and optimizes functional …

Polygenic risk scores (PRS) summarize genetic liability to a disease at the individual level,
and the aim is to use them as biomarkers of disease and poor outcomes in real-world …

Psychiatric disorders impose tremendous economic burden on society and are leading
causes of disability worldwide. However, only limited drugs are available for psychiatric …

Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability
than most other psychiatric disorders. The contribution to biological understanding from …