[HTML][HTML] Local genetic correlations exist among neurodegenerative and neuropsychiatric diseases

RH Reynolds, AZ Wagen, F Lona-Durazo… - npj Parkinson's …, 2023 - nature.com
Genetic correlation (rg) between traits can offer valuable insight into underlying shared
biological mechanisms. Neurodegenerative diseases overlap neuropathologically and often …

Genetic origins of schizophrenia find common ground

CO Iyegbe, PF O'Reilly - 2022 - nature.com
Genetic origins of schizophrenia find common ground Skip to main content Thank you for
visiting nature.com. You are using a browser version with limited support for CSS. To obtain the …

[HTML][HTML] Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration

I Austin-Zimmerman, DF Levey… - Nature …, 2023 - nature.com
Sleep duration has been linked to a wide range of negative health outcomes and to reduced
life expectancy. We present genome-wide association studies of short (≤ 5 h) and long (≥ …

[HTML][HTML] Characterising the shared genetic determinants of bipolar disorder, schizophrenia and risk-taking

G Hindley, S Bahrami, NE Steen, KS O'Connell… - Translational …, 2021 - nature.com
Increased risk-taking is a central component of bipolar disorder (BIP) and is implicated in
schizophrenia (SCZ). Risky behaviours, including smoking and alcohol use, are …

[HTML][HTML] The next 10 years of behavioural genomic research

R Plomin - JCPP advances, 2022 - ncbi.nlm.nih.gov
Background The explosion caused by the fusion of quantitative genetics and molecular
genetics will transform behavioural genetic research in child and adolescent psychology …

[HTML][HTML] Immune marker levels in severe mental disorders: associations with polygenic risk scores of related mental phenotypes and psoriasis

MCF Werner, KV Wirgenes, A Shadrin… - Translational …, 2022 - nature.com
Several lines of evidence implicate immune abnormalities in the pathophysiology of severe
mental disorders (SMD) and comorbid mental disorders. Here, we use the data from …

[HTML][HTML] Patients with schizophrenia and bipolar disorder display a similar global gene expression signature in whole blood that reflects elevated proportion of …

A Torsvik, HR Brattbakk, A Trentani, R Holdhus… - Translational …, 2023 - nature.com
Schizophrenia (SCZ) and bipolar disorder (BD) share clinical characteristics, genetic
susceptibility, and immune alterations. We aimed to identify differential transcriptional …

The genetic architecture of the corpus callosum and its genetic overlap with common neuropsychiatric diseases

SJ Chen, BS Wu, YJ Ge, SD Chen, YN Ou… - Journal of Affective …, 2023 - Elsevier
Background The corpus callosum (CC) is the main structure transferring information
between the cerebral hemispheres. Although previous large-scale genome-wide …

[HTML][HTML] Leveraging genetic overlap between irritability and psychiatric disorders to identify genetic variants of major psychiatric disorders

K Jung, J Yoon, Y Ahn, S Kim, I Shim, H Ko… - … & Molecular Medicine, 2023 - nature.com
Irritability is a heritable core mental trait associated with several psychiatric illnesses.
However, the genomic basis of irritability is unclear. Therefore, this study aimed to 1) identify …

[HTML][HTML] Multivariate genomic architecture of cortical thickness and surface area at multiple levels of analysis

AD Grotzinger, TT Mallard, Z Liu, J Seidlitz, T Ge… - Nature …, 2023 - nature.com
Recent work in imaging genetics suggests high levels of genetic overlap within cortical
regions for cortical thickness (CT) and surface area (SA). We model this multivariate system …