Inhibitors against DNA Polymerase I Family of Enzymes: Novel Targets and Opportunities
Simple Summary DNA polymerases are essential enzymes for the growth and survival of a
cell. These enzymes replicate and/or repair the cellular genome. Some DNA polymerases …
cell. These enzymes replicate and/or repair the cellular genome. Some DNA polymerases …
Natural history of eukaryotic DNA viruses with double jelly-roll major capsid proteins
M Krupovic, JH Kuhn, MG Fischer… - Proceedings of the …, 2024 - National Acad Sciences
The phylum Preplasmiviricota (kingdom Bamfordvirae, realm Varidnaviria) is a broad
assemblage of diverse viruses with comparatively short double-stranded DNA genomes (< …
assemblage of diverse viruses with comparatively short double-stranded DNA genomes (< …
A conserved polar residue plays a critical role in mismatch detection in A-family DNA polymerases
PC Clement, T Sapam, DT Nair - International Journal of Biological …, 2024 - Elsevier
In A-family DNA polymerases (dPols), a functional 3′-5′ exonuclease activity is known to
proofread newly synthesized DNA. The identification of a mismatch in substrate DNA leads …
proofread newly synthesized DNA. The identification of a mismatch in substrate DNA leads …
The plant organellar primase-helicase directs template recognition and primosome assembly via its zinc finger domain
A Peralta-Castro, F Cordoba-Andrade… - BMC Plant …, 2023 - Springer
Background The mechanisms and regulation for DNA replication in plant organelles are
largely unknown, as few proteins involved in replisome assembly have been biochemically …
largely unknown, as few proteins involved in replisome assembly have been biochemically …
Engineering psychrophilic polymerase for nanopore long-read sequencing
Y Sun, DH Ko, J Gao, K Fu, Y Mao, Y He… - … in Bioengineering and …, 2024 - frontiersin.org
Unveiling the potential application of psychrophilic polymerases as candidates for
polymerase-nanopore long-read sequencing presents a departure from conventional …
polymerase-nanopore long-read sequencing presents a departure from conventional …
Mitochondrial mutation spectrum in Chordates: damage versus replication signatures, causes, and dynamics
To elucidate the primary factors shaping mitochondrial DNA (mtDNA) mutagenesis, we
reconstructed a deep 192-component mtDNA mutational spectrum using 129,100 …
reconstructed a deep 192-component mtDNA mutational spectrum using 129,100 …
Jumping DNA polymerases in bacteriophages
N Yutin, P Mutz, YI Wolf, M Krupovic, EV Koonin - bioRxiv, 2024 - biorxiv.org
Viruses with double-stranded (ds) DNA genomes in the realm Duplodnaviria share a
conserved structural gene module but show a broad range of variation in their repertoires of …
conserved structural gene module but show a broad range of variation in their repertoires of …
DNA polymerase gamma subunit 1 mediates the selective elimination of mutant mtDNA from the Drosophila female germline
SP Jeedigunta - 2023 - search.proquest.com
Mitochondrial DNA (mtDNA) encodes essential components of the oxidative
phosphorylation machinery which is the major source of cellular ATP. mtDNA is susceptible …
phosphorylation machinery which is the major source of cellular ATP. mtDNA is susceptible …