The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 has become a serious
challenge for medicine and science. Analysis of the molecular mechanisms associated with …

An intermediate of tricarboxylic acid cycle alpha-ketoglutarate (AKG) is involved in
pleiotropic metabolic and regulatory pathways in the cell, including energy production …

The activity of the mitochondrial permeability transition pore, mPTP, a highly regulated multi-
component mega-channel, is enhanced in aging and in aging-driven degenerative …

Both life span and health span are influenced by genetic, environmental and lifestyle factors.
With the genetic influence on human life span estimated to be about 20–25%, epigenetic …

Aging is a complex process indicated by low energy levels, declined physiological activity,
stress induced loss of homeostasis leading to the risk of diseases and mortality. Recent …

Sex differences in lifespan are well recognized in the majority of animal species. For
example, in male versus female Drosophila melanogaster there are significant differences in …

In recent years, intermittent fasting (IF) and its numerous modifications have been
increasingly suggested as a promising therapy for age-related problems and a non …

Metabolic disorders, such as diabetes mellitus (DM), are increasingly becoming significant
risk factors for the health of the global population and consume substantial portions of the …

One of the challenges facing science/biology today is uncovering the molecular bases that
support and determine animal and human longevity. Nature, in offering a diversity of animal …

Cells must be able to respond and adapt to different stress conditions to maintain normal
function. A common response to stress is the global inhibition of protein synthesis. Protein …