Endothelial Dysfunction, Inflammation, and Oxidative Stress in COVID‐19—Mechanisms and Therapeutic Targets
The outbreak of the COVID‐19 pandemic represents an ongoing healthcare emergency
responsible for more than 3.4 million deaths worldwide. COVID‐19 is the disease caused by …
responsible for more than 3.4 million deaths worldwide. COVID‐19 is the disease caused by …
JAK-STAT signaling in human disease: From genetic syndromes to clinical inhibition
Since its discovery, the Janus kinase-signal transduction and activation of transcription (JAK-
STAT) pathway has become recognized as a central mediator of widespread and varied …
STAT) pathway has become recognized as a central mediator of widespread and varied …
IL-6 and IL-10 as predictors of disease severity in COVID-19 patients: results from meta-analysis and regression
Abstract Aims SARS-CoV-2, an infectious agent behind the ongoing COVID-19 pandemic,
induces high levels of cytokines such as IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ etc in …
induces high levels of cytokines such as IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ etc in …
[HTML][HTML] Biomarkers for prognosis and treatment response in COVID-19 patients
During a severe infection such as coronavirus disease 2019 (COVID-19), the level of almost
all analytes can change, presenting a correlation with disease severity and survival; …
all analytes can change, presenting a correlation with disease severity and survival; …
Ischemic gastrointestinal complications of COVID-19: a systematic review on imaging presentation
Background Limited data is available addressing gastrointestinal (GI) ischemia in
coronavirus disease 2019 (COVID-19). We reviewed the clinical and radiologic features of …
coronavirus disease 2019 (COVID-19). We reviewed the clinical and radiologic features of …
[HTML][HTML] Metabolic syndrome and COVID-19
H Yanai - Cardiology research, 2020 - ncbi.nlm.nih.gov
Recent studies showed that comorbidities such as diabetes, hypertension and obesity
contribute to severe and worse outcomes of coronavirus disease 2019 (COVID-19) …
contribute to severe and worse outcomes of coronavirus disease 2019 (COVID-19) …
The tryptophan catabolite or kynurenine pathway in COVID-19 and critical COVID-19: a systematic review and meta-analysis
AF Almulla, T Supasitthumrong… - BMC Infectious …, 2022 - Springer
Abstract Background Coronavirus disease 2019 (COVID-19) is accompanied by activated
immune-inflammatory pathways and oxidative stress, which both induce indoleamine-2, 3 …
immune-inflammatory pathways and oxidative stress, which both induce indoleamine-2, 3 …
The impact of COVID-19 infection on the cytokine profile of pregnant women: A prospective case-control study
Objective To compare the levels of various cytokines between pregnant women with
confirmed coronavirus disease (COVID-19) infection and pregnant women without any …
confirmed coronavirus disease (COVID-19) infection and pregnant women without any …
IL-4/IL-13 remodeling pathway of COVID-19 lung injury
CB Vaz de Paula, MLV de Azevedo, S Nagashima… - Scientific Reports, 2020 - nature.com
The COVID-19 fatality rate is high when compared to the H1N1pdm09 (pandemic Influenza
A virus H1N1 subtype) rate, and although both cause an aggravated inflammatory response …
A virus H1N1 subtype) rate, and although both cause an aggravated inflammatory response …
[HTML][HTML] Nitazoxanide superiority to placebo to treat moderate COVID-19–A Pilot prove of concept randomized double-blind clinical trial.
VF Blum, S Cimerman, JR Hunter, P Tierno… - …, 2021 - thelancet.com
Background The absence of specific antivirals to treat COVID-19 leads to the repositioning
of candidates' drugs. Nitazoxanide (NTZ) has a broad antiviral effect. Methods This was a …
of candidates' drugs. Nitazoxanide (NTZ) has a broad antiviral effect. Methods This was a …