I Ryoo, MK Kwak - Toxicology and applied pharmacology, 2018 - Elsevier
Mitochondria play essential roles in cellular bioenergetics, biosynthesis, and apoptosis. During the process of respiration and oxidative phosphorylation, mitochondria utilize oxygen …
W Zhang, X Hu, Q Shen, D Xing - Nature communications, 2019 - nature.com
Cancer cells exhibit slightly elevated levels of reactive oxygen species (ROS) compared with normal cells, and approximately 90% of intracellular ROS is produced in mitochondria. In …
PS Brookes, Y Yoon, JL Robotham… - … of Physiology-Cell …, 2004 - journals.physiology.org
The mitochondrion is at the core of cellular energy metabolism, being the site of most ATP generation. Calcium is a key regulator of mitochondrial function and acts at several levels …
H Jin, A Kanthasamy, A Ghosh, V Anantharam… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Parkinson's disease is a progressive neurodegenerative disease in the elderly, and no cure or disease-modifying therapies exist. Several lines of evidence suggest that mitochondrial …
P Bullon, HN Newman, M Battino - Periodontology 2000, 2014 - Wiley Online Library
As many diseases have been shown to have several or indirect causes (ie are multifactorial) the question is what is the relative importance of each factor in a given disease? Also, what …
The increase in human life expectancy has become a challenge to reduce the deleterious consequences of aging. Nowadays, an increasing number of the population suffer from age …
MA Savitskaya, GE Onishchenko - Biochemistry (Moscow), 2015 - Springer
Nearly 15 types of programmed cell death (PCD) have been identified to date. Among them, apoptosis is the most common and well-studied type of PCD. In this review, we discuss …
SR Pieczenik, J Neustadt - Experimental and molecular pathology, 2007 - Elsevier
Since the first mitochondrial dysfunction was described in the 1960s, the medicine has advanced in its understanding the role mitochondria play in health, disease, and aging. A …
D Bou-Teen, N Kaludercic, D Weissman… - Free Radical Biology …, 2021 - Elsevier
Excessive mitochondrial ROS production has been causally linked to the pathophysiology of aging in the heart and other organs, and plays a deleterious role in several age-related …