The role of brain cell-type-specific functions and profiles in pathological and non-
pathological contexts is still poorly defined. Such cell-type-specific gene expression profiles …

Molecular changes at synapses are thought to underly the deficits in motor and cognitive
dysfunction seen in Huntington's disease (HD). Previously we showed in synaptosome …

One of the more transformative findings in human genetics was the discovery that the
expansion of unstable nucleotide repeats underlies a group of inherited neurological …

While Huntington disease (HD) is caused solely by a polyglutamine expansion in the
huntingtin gene, environmental factors can influence HD onset and progression. Here, we …

Posttranslational modifications can have profound effects on the biological and biophysical
properties of proteins associated with misfolding and aggregation. However, their detection …

Amyloid beta (Aβ) peptides impair multiple cellular pathways and play a causative role in
Alzheimer's disease (AD) pathology, but how the brain proteome is remodeled by this …

Transcriptional regulatory changes in the developing and adult brain are prominent features
of brain diseases, but the involvement of specific transcription factors (TFs) remains poorly …

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an
expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock‐in …

Huntington's disease (HD) affects both neurons and astrocytes. To target the latter and to
ensure brain-wide transgene expression, adeno-associated viral (AAV) vectors can be …

Huntington's disease (HD) is a devastating and fatal monogenic neurodegenerative disorder
characterized by progressive loss of selective neurons in the brain and is caused by an …