Ontogeny and Function of Plasmacytoid Dendritic Cells

NM Adams, A Das, TJ Yun… - Annual Review of …, 2024 - annualreviews.org
Plasmacytoid dendritic cells (pDCs) represent a unique cell type within the innate immune
system. Their defining property is the recognition of pathogen-derived nucleic acids through …

The role of plasmacytoid dendritic cells (pDCs) in immunity during viral infections and beyond

C Ngo, C Garrec, E Tomasello, M Dalod - Cellular & Molecular …, 2024 - nature.com
Type I and III interferons (IFNs) are essential for antiviral immunity and act through two
different but complimentary pathways. First, IFNs activate intracellular antimicrobial …

SARS-CoV-2 infection triggers pro-atherogenic inflammatory responses in human coronary vessels

N Eberhardt, MG Noval, R Kaur, L Amadori… - Nature cardiovascular …, 2023 - nature.com
Patients with coronavirus disease 2019 (COVID-19) present increased risk for ischemic
cardiovascular complications up to 1 year after infection. Although the systemic inflammatory …

The immunobiology of corneal HSV-1 infection and herpetic stromal keratitis

F Antony, D Kinha, A Nowińska, BT Rouse… - Clinical Microbiology …, 2024 - journals.asm.org
SUMMARY Human alphaherpesvirus 1 (HSV-1) is a highly successful neurotropic pathogen
that primarily infects the epithelial cells lining the orofacial mucosa. After primary lytic …

Microplastics dysregulate innate immunity in the SARS-CoV-2 infected lung

CR Bishop, K Yan, W Nguyen, DJ Rawle… - Frontiers in …, 2024 - frontiersin.org
Introduction Global microplastic (MP) pollution is now well recognized, with humans and
animals consuming and inhaling MPs on a daily basis, with a growing body of concern …

Cytokine storm and translating IL-6 biology into effective treatments for COVID-19

T Li, D Wang, H Wei, X Xu - Frontiers of Medicine, 2023 - Springer
Abstract As of May 3, 2023, the Coronavirus disease 2019 (COVID-19) pandemic has
resulted in more than 760 million confirmed cases and over 6.9 million deaths. Several …

SARS-CoV-2 Spike Protein Stimulates Macropinocytosis in Murine and Human Macrophages via PKC-NADPH Oxidase Signaling

WM Ahn, FN Burnett, A Pandey, P Ghoshal, B Singla… - Antioxidants, 2024 - mdpi.com
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). While recent studies have demonstrated …

Robust senescence evaluation by transcriptome-based hUSI to facilitate characterizing cellular senescence under various conditions

T Ni, J Wang, W Wang, J Yao, X Zhou, G Wei - 2024 - researchsquare.com
Despite the manifestation and contribution of cellular senescence to tissue aging and aging-
related disease, the identification of in vivo senescent cells and the recognition of …

SARS-CoV2 infection in whole lung primarily targets macrophages that display subset-specific responses

TPV Manh, C Gouin, J De Wolf, L Jouneau, F Pascale… - 2024 - researchsquare.com
Deciphering the initial steps of SARS-CoV-2 infection, that influence COVID-19 outcomes, is
challenging because animal models do not always reproduce human biological processes …

Tropisme cellulaire initial du SARS-CoV-2 dans le poumon humain: du poumon entier aux sous-populations de macrophages

C Gouin - 2023 - theses.hal.science
Les mécanismes pathogéniques impliqués dans les phases initiales de l'infection par le
SARS-CoV-2 restent mal compris au niveau pulmonaire, en dépit d'une abondante activité …