Introduction Advanced paternal age of reproduction is an increasing trend, especially in
developed countries and areas. This trend results in elevated risks of adverse reproductive …

Cigarette smoke (CS) leads to increased oxidative stress, inflammation, and exaggerated
senescence, which are involved in the pathogenesis of chronic obstructive pulmonary …

Senescence is linked to a wide range of age-associated diseases and physiological
declines. Thus, senotherapeutics are emerging to suppress the detrimental effects of …

Iron imbalance in the brain negatively affects brain function. With aging, iron levels increase
in the brain and contribute to brain damage and neurological disorders. Changes in the …

In advanced age, increases in oxidative stress and inflammation impair endothelial function,
which contributes to the development of cardiovascular disease (CVD). One plausible …

Abstract Background PLA2G6-Associated Neurodegeneration (PLAN) is a rare
neurodegenerative disease with autosomal recessive inheritance, which belongs to the …

Obesity is a major risk factor for cancer. Conventional thought suggests that elevated
adiposity predisposes to heightened inflammatory stress and potentiates tumor growth, yet …

Pharmacologically active compounds that manipulate cellular senescence (senotherapies)
have recently shown great promise in multiple pre-clinical disease models, and some of …

Aging increases the risk of atherosclerotic cardiovascular disease which is associated with
arterial senescence; however, the mechanisms responsible for the development of cellular …

Specific imaging of cellular senescence emerges as a promising strategy for early diagnosis
and treatment of various age-related diseases. The currently available imaging probes are …