Fibrosing interstitial lung disease (ILD) develops due to the impaired reparative processes
following lung tissue damage. Cellular senescence has been reported to contribute to the …

Modern understanding of aging is based on the accumulation of cellular damage during
one's life span due to the gradual deterioration of regenerative mechanisms in response to …

Literature reviews are valuable resources for the scientific community. With research
accelerating at an unprecedented speed in recent years and more and more original papers …

The highest risk factor for the development of neurodegenerative diseases like tauopathies
is aging. Many physiological decrements underlying aging are linked to cellular …

F-box and WD repeat domain containing 7 (FBXW7) acts as a substrate receptor of SKP1-
CUL1-F-box (SCF) E3 ubiquitin ligase and plays crucial roles in the regulation of several …

Accumulation of senescent cells with age leads to tissue dysfunction and related diseases.
Their detection in vivo still constitutes a challenge in aging research. We describe the …

Accumulation of senescent chondrocytes is thought to drive inflammatory processes and
subsequent cartilage degeneration in age-related as well as posttraumatic osteoarthritis …

Society and our healthcare system are facing unprecedented challenges due to the
expansion of the older population. As plastic surgeons, we can improve care of our older …

Senescence occurs in response to a number of damaging stimuli to limit oncogenic
transformation and cancer development. As no single, universal senescence marker has …

Purpose Despite the beneficial effects of chemotherapy, therapy-induced senescence (TIS)
manifests itself as an undesirable byproduct. Preclinical evidence suggests that tumor cells …