Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Over the past decade, a growing number of studies have revealed that progressive changes
to epigenetic information accompany aging in both dividing and nondividing cells …

Cardiovascular disease (CVD) presents a great burden for elderly patients, their caregivers,
and health systems. Structural and functional alterations of vessels accumulate throughout …

Epidemiologic studies show that 11% of the world's population is over 60 years of age; this
is projected to increase, by 2050, to 22% of the population. Oral aging is a current focus of …

While the liver demonstrates remarkable resilience during aging, there is growing evidence
that it undergoes all the cellular hallmarks of aging, which increases the risk of liver and …

Human mesenchymal stem cells (MSCs) are primary multipotent cells capable of
differentiating into osteocytes, chondrocytes, and adipocytes when stimulated under …

With ageing, bone tissue undergoes significant compositional, architectural and metabolic
alterations potentially leading to osteoporosis. Osteoporosis is the most prevalent bone …

Aging is an inevitable process of life. Defined by progressive physiological and functional
loss of tissues and organs, aging increases the risk of mortality for the organism. The aging …

Cellular and molecular aging biomarkers might contribute to identify at-risk individuals for
frailty before overt clinical manifestations appear. Although studies on the associations of …

Nuclear deformation, a hallmark frequently observed in senescent cells, is presumed to be
associated with the erosion of chromatin organization at the nuclear periphery. However …