A growing body of evidence suggests that epigenetic modifications—changes to the
genome that do not involve changes in DNA sequence—may significantly derail …

Objectives: Firefighters have elevated cancer incidence and mortality rates. MicroRNAs play
prominent roles in carcinogenesis, but have not been previously evaluated in firefighters …

Systemic sclerosis-associated fibrosis: an accelerated aging... : Current Opinion in
Rheumatology Systemic sclerosis-associated fibrosis: an accelerated aging phenotype …

Background A critical feature for fibroblasts differentiation into myofibroblasts is the
expression of alpha‐smooth muscle actin (α‐SMA) during the tissue injury and repair …

Histone H4 lysine16 acetylation (H4K16Ac) modulates chromatin structure by serving as a
switch from a repressive to a transcriptionally active state. This euchromatin mark is …

Although books exist on the evolution of aging, this is the first book written from the
perspective of again as an adaptive program. It offers an insight into the implications of …

Alzheimer's disease (AD) is an irreversible, progressive neurodegenerative disease and the
most common cause of dementia among older adults. There are no effective treatments …

Background The causal relationship and the direction of the effect between depression and
aging remain controversial. Methods We used a bidirectional two-sample Mendelian …

Mounting evidence indicates that histone modifications are involved in aging-associated
cognitive decline (AACD) and can be transmitted to offspring over multiple generations …

The trajectory of human aging varies widely from one individual to the next due to complex
interactions between the genome and the environment that influence the aging process …