Current and prospective applications of metal ion–protein binding

EKM Ueda, PW Gout, L Morganti - Journal of chromatography A, 2003 - Elsevier
Since immobilized metal ion affinity chromatography (IMAC) was first introduced, several
variants of this method and many other metal affinity-based techniques have been devised …

Tissue substitutes comprising stem cells and reduced ceria

K Sugaya, S Merchant, S Seal, P Georgieva… - US Patent …, 2011 - Google Patents
A biocompatible composite includes a solid biocompatible material and a plurality of living
human progenitor or living stem cells attached thereto. The biocomposite provides a stable …

Adenoviral-vector-mediated gene transfer into medullary motor neurons

F Finiels, M Gimenez-Ribotta, J Mallet, A Privat… - US Patent …, 2003 - Google Patents
The present invention relates to methods and compositions for delivering a nucleic acid to
motor neurons administering the nucleic acid to muscle tissue. The invention relates to …

Transgenic rabbit that expresses a functional human lipoprotein (a)

D Rouy, N Duverger, F Emmanuel, P Denefle… - US Patent …, 2003 - Google Patents
(57) ABSTRACT A transgenic rabbit Which has in its genomic DNA sequences that encode
apolipoprotein (a) and apolipoprotein B polypeptides Which are capable of combining to …

Viral vectors and their use for treating hyperproliferative disorders, in particular restenosis

D Branellec, K Walsh, JM Isner, P Denefle - US Patent 5,851,521, 1998 - Google Patents
hyperproliferative disorders which may be treated according to the invention are various
tumors and cardiovascular diseases, such as vascular restenosis resulting from mechanical …

Adenovirus-mediated intratumoral delivery of an angiogenesis antagonist for the treatment of tumors

H Li, H Lu, F Griscelli, P Opolon, C Soria, T Ragot… - 1998 - Google Patents
WO1998049321A2 - Adenovirus-mediated intratumoral delivery of an angiogenesis antagonist
for the treatment of tumors - Google Patents WO1998049321A2 - Adenovirus-mediated …

Method for producing recombinant virus

H Leblois-Prehaud, M Perricaudet, E Vigne… - US Patent …, 2002 - Google Patents
US6387670B1 - Method for producing recombinant virus - Google Patents US6387670B1 -
Method for producing recombinant virus - Google Patents Method for producing …

Antagonists of the oncogenic activity of the protein mdm2, and use thereof in the treatment of cancers

B Tocque, B Wasylyk… - US Patent App. 09 …, 2003 - Google Patents
The present invention relates to the utilization of a com pound capable of antagonizing at
least partially the onco genic activity of the protein Mdm2 for the preparation of a …

Variants of apolipoprotein AI

P Benoit, E Bruckert, P Denefle, N Duverger… - US Patent …, 2001 - Google Patents
The present invention relates to variants of the human apolipoproteine AI comprising a
cystein in position 151, the corresponding nucleic acids and the vectors containing them. It …

Variants of thymidine kinase, nucleic acids encoding them, and methods of using them

J Crouzet, F Blanche, M Couder, B Cameron - US Patent 6,207,150, 2001 - Google Patents
US6207150B1 - Variants of thymidine kinase, nucleic acids encoding them, and methods of
using them - Google Patents US6207150B1 - Variants of thymidine kinase, nucleic acids …