Hepatocellular carcinoma (HCC) is a common cancer worldwide that primarily develops in
cirrhosis resulting from chronic infection by hepatitis B virus and hepatitis C virus, alcoholic …

Hepatocarcinogenesis is a slow process during which genomic changes progressively alter
the hepatocellular phenotype to produce cellular intermediates that evolve into …

Normal tissues accumulate genetic changes with age, but it is unknown if somatic mutations
promote clonal expansion of non-malignant cells in the setting of chronic degenerative …

Chronic liver disease and primary liver cancer are a massive global problem, with a future
increase in incidences predicted. The most prevalent form of primary liver cancer …

Materials and Methods Twenty-six resected cases of nodules from 23 patients with chronic
hepatitis or cirrhosis caused by hepatitis B or Abbreviations: GPC3, glypican-3; GS …

Numerous genetic alterations are accumulated during the process of hepatocarcinogenesis.
These genetic alterations can be divided into two groups. The first set of genetic alterations …

Polyploidy has been described in the liver for over 100 years. The frequency of polyploid
hepatocytes varies by age and species, but up to 90% of mouse hepatocytes and …

As discussed in detail in other chapters of this review, chronic hepatitis B (HBV) infection is a
major risk factor for hepatocellular carcinoma (HCC). Most HCCs complicate the evolution of …

Hepatocellular carcinoma (HCC) is the most common histological form of primary liver
cancer, the tumor cells having retained features of hepatocytic differentiation. It is important …

Context.—There is increasing evidence to support a multistep model of the process of
human hepatocarcinogenesis. Precursor lesions are characterized by the appearance of …