Only a few years after the introduction of levodopa, the first descriptions of motor fluctuations
and dyskinesia related to dopaminergic therapy appeared. In PD, attention turned to their …

Pain is a very frequent symptom with influence on the quality of life in Parkinson's disease
(PD), but is still underdiagnosed and commonly treated only unsystematically. Pain etiology …

Background Pain is a common non-motor symptom of Parkinson's disease. We investigated
the analgesic efficacy of prolonged-release oxycodone–naloxone (OXN PR) in patients with …

Health-related quality of life (HRQoL) is defined as “the perception and evaluation by
patients themselves of the impact caused on their lives by the disease and its …

Pain and sensory abnormalities are present in a large proportion of Parkinson disease (PD)
patients and have a significant negative impact in quality of life. It remains undetermined …

Background: Pain, a frequent non-motor symptom in Parkinson's Disease (PD), significantly
impacts on quality of life. Safinamide is a new drug with dopaminergic and non …

Pain is a troublesome nonmotor symptom of Parkinson's disease (PD). This double‐blind
exploratory pilot study (NCT01744496) was the first to specifically investigate the effect of a …

Nonmotor manifestations in Parkinson's disease (PD) encompass a range of clinical
features, including neuropsychiatric problems, autonomic dysfunction, sleep disorders …

Pain is a common and disabling non-motor symptom (NMS) of Parkinson's disease (PD),
which occurs through the course of the disease, often unrecognized and undertreated. For …

Non-motor symptoms (NMS) are common among patients with Parkinson's disease and
reduce patients' quality of life (QOL). However, there remain considerable unmet needs for …