Schizophrenia continues to be an illness with poor outcome. Most mechanistic changes
occur many years before the first episode of schizophrenia; these are not reversible after the …

The deviation between chronological age and age predicted using brain MRI is a putative
marker of overall brain health. Age prediction based on structural MRI data shows high …

T1-weighted divided by T2-weighted (T1w/T2w) myelin maps were initially developed for
neuroanatomical analyses such as identifying cortical areas, but they are increasingly used …

Across the major psychiatric disorders (MPDs), a shared disruption in brain physiology is
suspected. Here we investigate the neural variability at rest, a well-established behavior …

Myelin deficiency is commonly recognized as an important pathological feature of brain
tissues in schizophrenia (SZ). In this pilot study, global myelin content abnormalities in white …

Background Brain imaging studies have thoroughly investigated brain gray matter
abnormalities to assess pathophysiological mechanisms underlying psychiatric illnesses …

Whereas meta-analytical data highlight abnormal frontocortical macrostructure
(thickness/surface area/volume) in Major Depressive Disorder (MDD), the underlying …

Neuroimaging, genetic and molecular biological studies have shown impaired intra-cortical
myelination in patients with schizophrenia, particularly in the prefrontal cortex. Previously we …

Aberrations in intracortical myelination are increasingly being considered as a cardinal
feature in the pathophysiology of schizophrenia. We investigated the network-level …

Myelin abnormalities have been reported in schizophrenia spectrum disorders (SSD) in
white matter. However, in vivo examinations of cortical myeloarchitecture in SSD, especially …