The last few years have seen extensive efforts to catalogue human genetic variation and
correlate it with phenotypic differences. Most common SNPs have now been assessed in …

Animal modeling has been instrumental in dissecting pathophysiological mechanisms and
designing more effective therapies in many areas of medicine but not so in psychiatry. The …

Gene targeting, defined as the introduction of site-specific modifications into the genome by
homologous recombination, has revolutionarized the field of mouse genetics and allowed …

Transgenic rhesus monkeys carrying the green fluorescent protein (GFP) gene were
produced by injecting pseudotyped replication-defective retroviral vector into the perivitelline …

We have used gene targeting to create a mouse model of glycogen storage disease type II,
a disease in which distinct clinical phenotypes present at different ages. As in the severe …

There is growing evidence that chemokines and their receptors regulate the movement and
interaction of antigen-presenting cells such as dendritic cells (DCs) and T cells. We tested …

Bone morphogenetic protein 4 (Bmp4), a vertebrate homolog ofDrosophila decapentaplegic
(dpp), encodes a signaling protein with multiple functions during embryogenesis. Most …

Transgenic animals are an important source of protein and nutrition for most humans and
will play key roles in satisfying the increasing demand for food in an ever-increasing world …

Glypicans represent a family of six cell surface heparan sulfate proteoglycans in vertebrates.
Although no specific in vivo functions have thus far been described for these proteoglycans …

Genetic modifiers can be detected in mice by looking for strain background differences in
inheritance or phenotype of a mutation. They can be mapped by analyses of appropriate …