Loss of Bcl-6-expressing T follicular helper cells and germinal centers in COVID-19
Humoral responses in coronavirus disease 2019 (COVID-19) are often of limited durability,
as seen with other human coronavirus epidemics. To address the underlying etiology, we …
as seen with other human coronavirus epidemics. To address the underlying etiology, we …
Engineering human ACE2 to optimize binding to the spike protein of SARS coronavirus 2
The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
binds angiotensin-converting enzyme 2 (ACE2) on host cells to initiate entry, and soluble …
binds angiotensin-converting enzyme 2 (ACE2) on host cells to initiate entry, and soluble …
[HTML][HTML] Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding
The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral
attachment to ACE2 receptor and is a major determinant of host range and a dominant target …
attachment to ACE2 receptor and is a major determinant of host range and a dominant target …
[HTML][HTML] Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity
Limited knowledge is available on the relationship between antigen-specific immune
responses and COVID-19 disease severity. We completed a combined examination of all …
responses and COVID-19 disease severity. We completed a combined examination of all …
Selective and cross-reactive SARS-CoV-2 T cell epitopes in unexposed humans
Many unknowns exist about human immune responses to the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) virus. SARS-CoV-2–reactive CD4+ T cells have …
syndrome coronavirus 2 (SARS-CoV-2) virus. SARS-CoV-2–reactive CD4+ T cells have …
Longitudinal observation and decline of neutralizing antibody responses in the three months following SARS-CoV-2 infection in humans
Antibody responses to SARS-CoV-2 can be detected in most infected individuals 10–15 d
after the onset of COVID-19 symptoms. However, due to the recent emergence of SARS …
after the onset of COVID-19 symptoms. However, due to the recent emergence of SARS …
Spike and nsp6 are key determinants of SARS-CoV-2 Omicron BA. 1 attenuation
Abstract The SARS-CoV-2 Omicron variant is more immune evasive and less virulent than
other major viral variants that have so far been recognized,,,,,,,,,,–. The Omicron spike (S) …
other major viral variants that have so far been recognized,,,,,,,,,,–. The Omicron spike (S) …
A SARS-CoV-2 surrogate virus neutralization test based on antibody-mediated blockage of ACE2–spike protein–protein interaction
A robust serological test to detect neutralizing antibodies to SARS-CoV-2 is urgently needed
to determine not only the infection rate, herd immunity and predicted humoral protection, but …
to determine not only the infection rate, herd immunity and predicted humoral protection, but …
SARS-CoV-2 antibody prevalence in Brazil: results from two successive nationwide serological household surveys
PC Hallal, FP Hartwig, BL Horta, MF Silveira… - The Lancet Global …, 2020 - thelancet.com
Background Population-based data on COVID-19 are essential for guiding policies. There
are few such studies, particularly from low or middle-income countries. Brazil is currently a …
are few such studies, particularly from low or middle-income countries. Brazil is currently a …
The SARS-CoV-2 spike glycoprotein biosynthesis, structure, function, and antigenicity: implications for the design of spike-based vaccine immunogens
L Duan, Q Zheng, H Zhang, Y Niu, Y Lou… - Frontiers in …, 2020 - frontiersin.org
The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a grave threat to global public …
respiratory syndrome coronavirus 2 (SARS-CoV-2), poses a grave threat to global public …