It is clear that intramolecular hydrogen bonds are essential to the structure and stability of
globular proteins. It is not clear, however, whether they make a net favorable contribution to …

The major facilitator superfamily (MFS) is the largest family of secondary active transporters
and is present in all life kingdoms. Detailed structural basis of the substrate transport and …

RNA hairpin loops containing a GNRA consensus sequence are the most frequently
occurring hairpins in a variety of prokaryotic and eukaryotic RNAs. These tetraloops play …

Publisher Summary This chapter considers both the structure and function of α-lactalbumin
and lysozyme in relation to each other, and also the potential significance of the studies in …

Barnase is described anatomically in terms of its substructures and their mode of packing.
The surface area of hydrophobic residues buried on formation and packing of the structural …

Compound 1 (F), a nonpolar nucleoside analog that is isosteric with thymidine, has been
proposed as a probe for the importance of hydrogen bonds in biological systems. Consistent …

The tendency of a polypeptide chain to form alpha-helical or beta-strand secondary structure
depends upon local and nonlocal effects. Local effects reflect the intrinsic propensities of the …

A molecular dynamics simulation method is used to determine the contributions of individual
amino acid residues and solvent molecules to free energy changes in proteins. Its …

An overview is presented of some of the major insights that have come from studies of the
structure, stability, and folding of T4 phage lysozyme. A major purpose of this review is to …

Molecular and Cellular Biophysics provides advanced undergraduate and graduate
students with a foundation in the basic concepts of biophysics. Students who have taken …