The relationship between protein structure and stability is one of the key problems of modem
chemistry1w2. whose solution should contribute to a better understanding of another …

Publisher Summary This chapter provides an overview of the results and concepts that have
been put forward in the field of in nitro misassembly (coagulation, aggregation). Considering …

Revised Manuscript Received November 22, 1991 abstract: Threonine 59, a helix-capping
residue at the amino terminus of the longest helix in T4 phage lysozyme, was substituted …

To investigate the contribution to protein stability of electrostatic interactions between
charged surface residues, we have studied the effect of substituting three negatively …

To investigate the relation between protein stability and the predicted stabilities of individual
secondary structural elements, residue Pro86 in an α-helix in phage T4 lysozyme was …

Predicting how a point mutation alters a protein's stability can guide pharmaceutical drug
design initiatives which aim to counter the effects of serious diseases. Conducting …

Solvent‐binding sites were compared in 10 different crystal forms of phage T4 lysozyme that
were refined using data from 2.6 Å to 1.7 Å resolution. The sample included 18 …

We introduce a new software, Efficient Detection of Hydrogen Bonds (EDHB), that
systematically detects hydrogen bonds based on the nearest neighbors algorithm. EDHB …

Revised Manuscript Received August 29, 1995® abstract: Whether hydrogen bonds
between side chains are energetically significant in proteinsand peptides has been …

We present free energy perturbation calculations on the X-ray structure of native T4
lysozyme, the Thr-157—Val-157 mutant of T4 lysozyme, and on a tetrapeptide model that …