Systemic metabolism has to be constantly adjusted to the variance of food intake and even
be prepared for anticipated changes in nutrient availability. Therefore, the brain integrates …

New incretin-based pharmacotherapies provide efficient and safe therapeutic options to
curb appetite and produce weight loss in patients with obesity. Delivered systemically, these …

Peptide-based drug development for CNS disorders is challenged by poor blood-brain
barrier (BBB) penetrability of peptides. While acylation protractions (lipidation) have been …

Insulin exerts its actions not only on peripheral organs but is also transported into the brain
where it performs distinct functions in various brain regions. This review highlights recent …

The use of glucagon-like peptide-1 (GLP-1) receptor-based multi-agonists in the treatment of
type 2 diabetes and obesity holds great promise for improving glycaemic control and weight …

The past decades have witnessed the rise and fall of several, largely unsuccessful,
therapeutic attempts to bring the escalating obesity pandemic to a halt. Looking back to look …

Introdroduction Obesity and its associated metabolic conditions have become a significant
global health problem in recent years, with many people living with obesity fulfilling criteria …

Abstract Objective In Western society, high-caloric diets rich in fats and sugars have fueled
the obesity epidemic and its related disorders. Disruption of the body-brain communication …

There is increasing evidence that the activation of glucagon-like peptide-1 receptor (GLP-
1R) can be used as a therapeutic intervention for cognitive disorders. Here, we have …

The brain-gut neurocircuitry is proving to be finely involved in a wide range of physiological
functions. In this issue of Neuron, Ren et al. 1 show that adrenergic signaling suppresses …