Cancer progression results from activation of various signaling networks. Among these,
PI3K/Akt signaling contributes to proliferation, invasion, and inhibition of apoptosis …

Obesity, a worldwide epidemic, confers increased risk for multiple serious conditions,
including cancer, and is increasingly recognized as a growing cause of preventable cancer …

Liver cancer has the second highest worldwide cancer mortality rate and has limited
therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole …

Hepatocellular Carcinoma (HCC) is a highly aggressive cancer with mortality running
parallel to its incidence and has limited therapeutic options. Chronic liver inflammation and …

Primary liver cancer, the majority of which are hepatocellular carcinomas, is now the second
leading cause of cancer death worldwide. Hepatocellular carcinoma is a unique cancer that …

The epidemic of obesity has resulted in a parallel incremental burden of nonalcoholic fatty
liver disease (NAFLD) worldwide. Nonalcoholic fatty liver disease includes a spectrum of …

Background We previously reported that the incidence of hepatocellular carcinoma (HCC)
with non-viral etiologies increased rapidly between 1991 and 2010 in Japan. Methods To …

Nonalcoholic fatty liver disease (NAFLD) is the liver injury most often associated with
disorders of insulin resistance, including obesity, diabetes and the metabolic syndrome. The …

BACKGROUND Hepatocellular carcinoma (HCC) incidence has been increasing in the
United States for several decades; and, as the incidence of hepatitis C virus (HCV) infection …

Accumulating evidence links obesity with low-grade inflammation which may originate from
adipose tissue that secretes a plethora of pro-and anti-inflammatory cytokines termed …