Inactivated whole-virion vaccine BBV152/Covaxin elicits robust cellular immune memory to SARS-CoV-2 and variants of concern
R Vikkurthi, A Ansari, AR Pai, SN Jha, S Sachan… - Nature …, 2022 - nature.com
BBV152 is a whole-virion inactivated vaccine based on the Asp614Gly variant. BBV152 is
the first alum-imidazoquinolin-adjuvanted vaccine authorized for use in large populations …
the first alum-imidazoquinolin-adjuvanted vaccine authorized for use in large populations …
Immunity to SARS-CoV-2 up to 15 months after infection
Information concerning the longevity of immunity to SARS-CoV-2 following natural infection
may have considerable implications for durability of immunity induced by vaccines. Here, we …
may have considerable implications for durability of immunity induced by vaccines. Here, we …
Are COVID-19 vaccine boosters needed? The science behind boosters
RM Burckhardt, JJ Dennehy, LLM Poon, LJ Saif… - Journal of …, 2022 - Am Soc Microbiol
Waning vaccine-induced immunity coupled with the emergence of SARS-CoV-2 variants
has led to increases in breakthrough infections, prompting consideration for vaccine booster …
has led to increases in breakthrough infections, prompting consideration for vaccine booster …
First-in-human immunoPET imaging of COVID-19 convalescent patients using dynamic total-body PET and a CD8-targeted minibody
With most of the T cells residing in the tissue, not the blood, developing noninvasive
methods for in vivo quantification of their biodistribution and kinetics is important for studying …
methods for in vivo quantification of their biodistribution and kinetics is important for studying …
[HTML][HTML] Covid-19: virology, variants, and vaccines
Abstract As of 25 January 2022, over 349 million individuals have received a confirmed
diagnosis of covid-19, with over 5.59 million confirmed deaths associated with the SARS …
diagnosis of covid-19, with over 5.59 million confirmed deaths associated with the SARS …
[HTML][HTML] T cell receptor sequencing identifies prior SARS-CoV-2 infection and correlates with neutralizing antibodies and disease severity
BACKGROUND Measuring the immune response to SARS-CoV-2 enables assessment of
past infection and protective immunity. SARS-CoV-2 infection induces humoral and T cell …
past infection and protective immunity. SARS-CoV-2 infection induces humoral and T cell …
Persistence of immunity and impact of third dose of inactivated COVID-19 vaccine against emerging variants
KM Vadrevu, B Ganneru, S Reddy, H Jogdand… - Scientific reports, 2022 - nature.com
This is a comprehensive report on immunogenicity of COVAXIN® booster dose against
ancestral and Variants of Concern (VOCs) up to 12 months. It is well known that neutralizing …
ancestral and Variants of Concern (VOCs) up to 12 months. It is well known that neutralizing …
Unique properties of tissue-resident memory T cells in the lungs: implications for COVID-19 and other respiratory diseases
FR Carbone - Nature Reviews Immunology, 2023 - nature.com
Tissue-resident memory T (TRM) cells were originally identified as a tissue-sequestered
population of memory T cells that show lifelong persistence in non-lymphoid organs. That …
population of memory T cells that show lifelong persistence in non-lymphoid organs. That …
Heterogenous humoral and cellular immune responses with distinct trajectories post-SARS-CoV-2 infection in a population-based cohort
To better understand the development of SARS-CoV-2-specific immunity over time, a
detailed evaluation of humoral and cellular responses is required. Here, we characterize …
detailed evaluation of humoral and cellular responses is required. Here, we characterize …
Hallmarks of immune response in COVID-19: Exploring dysregulation and exhaustion
One and half year following the occurrence of COVID-19 pandemic, significant efforts from
laboratories all over the world generated a huge amount of data describing the prototypical …
laboratories all over the world generated a huge amount of data describing the prototypical …