Negative psychological and physiological consequences of neurodegenerative disorders
represent a high social and health cost. Among the neurodegenerative disorders …

Ageing is accompanied by increasing vulnerability to major pathologies (atherosclerosis,
Alzheimer's disease, age-related macular degeneration, cataract, and osteoporosis) which …

The ability to investigate therapeutic interventions in animal models of neurodegenerative
diseases depends on extensive characterization of the model (s) being used. There are …

High serum/plasma cholesterol levels have been suggested as a risk factor for Alzheimer's
disease (AD). Some reports, mostly retrospective epidemiological studies, have observed a …

Alzheimer's disease (AD) is the most common cause of dementia in the elderly population,
currently affecting 46 million people worldwide. Histopathologically, the disease is …

Cardiovascular diseases, like atherosclerosis, and neurodegenerative diseases affecting
the central nervous system (CNS) are closely linked to alterations of cholesterol metabolism …

Macroautophagy/autophagy failure with the accumulation of autophagosomes is an early
neuropathological feature of Alzheimer disease (AD) that directly affects amyloid beta (Aβ) …

Conversion of β-amyloid (Aβ) peptides from soluble random-coil to aggregated protein
enriched with β-sheet-rich intermediates has been suggested to play a role in the …

Brain is a central and pivotal organ of human body containing the highest lipids content next
to adipose tissue. It works as a monitor for the whole body and needs an adequate supply of …

Extracellular neuritic plaques, composed of aggregated amyloid-β (Aβ) peptides, are one of
the major histopathological hallmarks of Alzheimer's disease (AD), a progressive …