The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling
pathway serves as a pivotal mediator of innate immunity by triggering the secretion of type I …

Traumatic brain injury (TBI) triggers a plethora of inflammatory events in the brain that
aggravate secondary injury and impede tissue repair. Resident microglia (Mi) and blood …

Traumatic brain injury (TBI) is a universal leading cause of long-term neurological disability
and causes a huge burden to an ever-growing population. Moderate intensity of treadmill …

In the past decade, there has been an increasing awareness that traumatic brain injury (TBI)
and concussion substantially increase the risk for developing psychiatric disorders. Even …

Background Neuroinflammation is one of the most important pathogeneses in secondary
brain injury after traumatic brain injury (TBI). Neutrophil extracellular traps (NETs) forming …

Microglia, the immune sentinels of the central nervous system (CNS), have emerged to be
the central players in many neurological and neurodegenerative diseases. Recent studies …

The cyclic guanosine monophosphate–adenosine monophosphate (GMP‐AMP) synthase‐
Stimulator of Interferon Genes (cGAS‐STING) pathway is a critical innate immune …

Cytoplasmic microbial and host aberrant DNAs act as danger signals and trigger host
immune responses. Upon recognition, the cytosolic DNA sensor cyclic GMP–AMP synthase …

Neuroinflammation driven by type-I interferons in the CNS is well established to exacerbate
the progression of many CNS pathologies both acute and chronic. The role of adaptor …

Stimulator of interferon genes (STING) is an innate immune signaling protein critical to
infections, autoimmunity, and cancer. STING signaling is also emerging as an exciting and …