The aftermath of TBI is associated with an acute stress response and the accumulation of
insoluble protein aggregates. Even after the symptoms of TBI are resolved, insidious …

Abstract Type-2 diabetes mellitus (T2DM) is associated with neuroinflammation and
cognitive decrement. Necroptosis programmed necrosis is emerging as the major …

CD4+ T cells, also known as T helper (Th) cells, contribute to the adaptive immunity both in
the periphery and in the central nervous system (CNS). At least seven subsets of Th cells …

Adropin is a versatile peptide which was discovered as a novel metabolic hormone that is
involved in the regulation of lipid and glucose homeostasis. However, its possible role in the …

Background: Chronic cerebral hypoperfusion (CCH) is commonly accompanied by brain
injury and glial activation. In addition to white matter lesions, the intensity of CCH greatly …

Tuberculosis (TB) is the leading cause of human death worldwide due to Mycobacterium
tuberculosis (Mtb) infection. Mtb infection can cause macrophage pyroptosis. PERK, as a …

Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is a major signal
transducer of the endoplasmic reticulum stress response (ERSR) pathway. Outcomes of …

Microglial cells are well‐known phagocytic cells that are resistant to the central nervous
system (CNS) and play an important role in the maintenance of CNS homeostasis. Activated …

Neuroinflammation, a pivotal factor in the pathogenesis of various brain disorders, including
neurodegenerative diseases, has become a focal point for therapeutic exploration. This …

Epilepsy is one of the most common neurology diseases. It is characterized by recurrent,
spontaneous seizures and accompanied by various comorbidities which can significantly …