Is TGR5 a therapeutic target for the treatment of spinal cord injury?

A Smaling, L Romero‐Ramírez… - Journal of …, 2023 - Wiley Online Library
Bile acids, which are synthesized in liver and colon, facilitate the digestion of dietary lipids.
In addition to this metabolic function, they also act as molecular signals with activities in the …

[HTML][HTML] Integrative analysis of TBI data reveals Lgmn as a key player in immune cell-mediated ferroptosis

L Yan, X Han, M Zhang, Y Fu, F Yang, Q Li, T Cheng - BMC genomics, 2023 - Springer
Background Traumatic brain injury (TBI) is a central nervous system disease caused by
external trauma, which has complex pathological and physiological mechanisms. The aim of …

ISRIB improves white matter injury following TBI by inhibiting NCOA4-mediated ferritinophagy

W Zhou, Y Liang, X Liao, L Tong, W Du, W Fu… - Neurochemistry …, 2024 - Elsevier
Traumatic brain injury (TBI) often results in persistent neurological dysfunction, which is
closely associated with white matter injury. The mechanisms underlying white matter injury …

TREM2 alleviates white matter injury after traumatic brain injury in mice might be mediated by regulation of DHCR24/LXR pathway in microglia

Z Li, S Yu, L Li, C Zhou, L Wang, S Tang… - Clinical and …, 2024 - Wiley Online Library
Background White matter injury (WMI) is an important pathological process after traumatic
brain injury (TBI). The correlation between white matter functions and the myeloid cells …

[HTML][HTML] Sjögren's syndrome and Parkinson's Disease: A bidirectional two-sample Mendelian randomization study

X Cai, Z Jin, S Zhang, J Liu, Z Jiang, F Tang, T Lan - Plos one, 2024 - journals.plos.org
Background Previous observational studies have reported an association between
Sjögren's syndrome (SS) and an increased risk of Parkinson's Disease (PD). However, the …

Minocycline improves the recovery of nerve function and alleviates blood-brain barrier damage by inhibiting endoplasmic reticulum in traumatic brain injury mice …

B Wang, W Lin, H Zhu - European Journal of Inflammation, 2021 - journals.sagepub.com
Traumatic brain injury (TBI) is a clinical emergency with a very high incidence, disability, and
fatality rate. Minocycline, a widely used semisynthetic second-generation tetracycline …

Activation of the Protein Kinase R–Like Endoplasmic Reticulum Kinase (PERK) pathway of the unfolded protein response after experimental traumatic brain injury and …

RD Brady, S Bird, M Sun, GR Yamakawa… - Neurotrauma …, 2021 - liebertpub.com
Neurodegeneration after traumatic brain injury (TBI) is increasingly recognized as a key
factor contributing to poor chronic outcomes. Activation (ie, phosphorylation) of the protein …

PERK inhibitor (ISRIB) improves depression-like behavior by inhibitions of HPA-axis over-activation in mice exposed to chronic restraint stress

L Luhong, H mao Zhou, X han Tang, J Chen… - Behavioural Brain …, 2024 - Elsevier
Stressful life event is closely associated with depression, thus strategies that blunt or prevent
the negative effect stress on the brain might benefits for the treatment of depression …

Protein tyrosine phosphatase 1B contributes to neuropathic pain by aggravating NF‐κB and glial cells activation‐mediated neuroinflammation via promoting …

B Jiao, W Zhang, C Zhang, K Zhang… - CNS Neuroscience …, 2024 - Wiley Online Library
Background Neuropathic pain is a prevalent and highly debilitating condition that impacts
millions of individuals globally. Neuroinflammation is considered a key factor in the …

PERK-STING signaling drives neuroinflammation in traumatic brain injury

AC Chin - Journal of Neuroscience, 2020 - Soc Neuroscience
Traumatic brain injury (TBI) resulting from excessive contact in sports, blast injuries in war, or
occupational hazards is a widespread public health concern. Symptoms associated with TBI …