Multiple Unfolded Protein Response pathways cooperate to link cytosolic dsDNA release to Stimulator of Interferon Gene (STING) activation

T Hu, Y Liu, J Fleck, C King, E Schalk, Z Zhang… - bioRxiv, 2024 - biorxiv.org
The double-stranded DNA (dsDNA) sensor STING has been increasingly implicated in
responses to sterile endogenous threats and pathogens without nominal DNA or cyclic di …

LysM-positive neurons drive Tuberous Sclerosis Complex (TSC)-associated brain lesions

J Zhang, S Xu, K Liang, X Cao, Z Ye, W Huang, X Bai… - Cellular …, 2022 - Elsevier
Abstract Mutations of Tsc1 or Tsc2 can lead to excessive activation of mTORC1 and cause
Tuberous Sclerosis Complex (TSC), which is an autosomal dominant genetic disease …

Integrative Analyses of Biomarkers Associated with endoplasmic reticulum stress in ischemic Stroke

X Zhang, X Li, J Gu, J Guo, J Chen… - … Methods in Medicine, 2022 - Wiley Online Library
Background. Neuronal apoptosis, which is the primary pathological transform of cerebral
injury following ischemic stroke (IS), is considered to be induced by endoplasmic reticulum …

[HTML][HTML] Gut Microbiota Shape Oligodendrocyte Response after Traumatic Brain Injury

K Shumilov, A Ni, M Garcia-Bonilla, M Celorrio… - Research …, 2024 - ncbi.nlm.nih.gov
White matter injury (WMI) is thought to be a major contributor to long-term cognitive
dysfunctions after traumatic brain injury (TBI). This damage occurs partly due to apoptotic …

[HTML][HTML] Antioxidant support to ameliorate the oxaliplatin-dependent microglial alteration: morphological and molecular study

JJV Branca, D Carrino, F Paternostro… - European Journal of …, 2021 - ncbi.nlm.nih.gov
Oxaliplatin is a third-generation chemotherapy drug mainly used for colorectal cancer
treatment. However, it is also known to trigger neuropathy whose underlying neurobiological …

The need for tissue-engineered models to facilitate the study of oligodendrocyte progenitor cells in traumatic brain injury and repair

RA Mazur, R Yokosawa, PJ VandeVord… - Current Opinion in …, 2022 - Elsevier
Traumatic brain injury (TBI) is an important public health issue as these high-rate
mechanical insults to brain tissue, even on a mild scale, progress to secondary injury …

The adolescent and the axon: Assessing the role of the ER in a murine model of traumatic optic neuropathy

S Hetzer - 2024 - rave.ohiolink.edu
Traumatic brain injury (TBI) is an incredibly heterogenous pathology, yet many of the current
mechanisms under exploration involve a common phenotype, traumatic axonal injury (TAI) …

[PDF][PDF] BRAIN COMMUNICATIONS

WS Hoogenboom, TG Rubin, K Ambadipudi, MH Cui… - 2023 - pdfs.semanticscholar.org
Correspondence may also be addressed to: Craig A. Branch Albert Einstein College of
Medicine and Montefiore Medical Center The Gruss Magnetic Resonance Research Center …

Nanoencapsulation of Withaferin-A for the Treatment of Neurological Disorder

S Sharma, DVS Viney Lather - Journal for ReAttach Therapy and …, 2022 - jrtdd.com
A better delivery mechanism is ensured by a superior formulation. This study is based on the
fact that people believe in natural products more than chemical products. Stress is a bad …

Injury-induced neuroinflammation alters addiction behavior

N Emmitt - 2022 - search.proquest.com
Traumatic brain injury (TBI) affects 64-74 million people every year worldwide. A history of
mild brain injury increases the risk of substance use disorder (SUD) by 2-6 times that of the …