Merozoite surface proteins in red blood cell invasion, immunity and vaccines against malaria
Malaria accounts for an enormous burden of disease globally, with Plasmodium falciparum
accounting for the majority of malaria, and P. vivax being a second important cause …
accounting for the majority of malaria, and P. vivax being a second important cause …
Recent clinical experience with vaccines using MPL-and QS-21-containing adjuvant systems
N Garcon, M Van Mechelen - Expert review of vaccines, 2011 - Taylor & Francis
The immunostimulants 3-O-desacyl-4'-monophosphoryl lipid A (MPL) and the saponin QS-
21 are part of licensed or candidate vaccines. MPL and QS-21 directly affect the innate …
21 are part of licensed or candidate vaccines. MPL and QS-21 directly affect the innate …
Structure-based design of a strain transcending AMA1-RON2L malaria vaccine
Abstract Apical membrane antigen 1 (AMA1) is a key malaria vaccine candidate and target
of neutralizing antibodies. AMA1 binds to a loop in rhoptry neck protein 2 (RON2L) to form …
of neutralizing antibodies. AMA1 binds to a loop in rhoptry neck protein 2 (RON2L) to form …
A field trial to assess a blood-stage malaria vaccine
MA Thera, OK Doumbo, D Coulibaly… - … England Journal of …, 2011 - Mass Medical Soc
Background Blood-stage malaria vaccines are intended to prevent clinical disease. The
malaria vaccine FMP2. 1/AS02A, a recombinant protein based on apical membrane antigen …
malaria vaccine FMP2. 1/AS02A, a recombinant protein based on apical membrane antigen …
A review of malaria vaccine clinical projects based on the WHO rainbow table
L Schwartz, GV Brown, B Genton, VS Moorthy - Malaria journal, 2012 - Springer
Abstract Development and Phase 3 testing of the most advanced malaria vaccine, RTS,
S/AS01, indicates that malaria vaccine R&D is moving into a new phase. Field trials of …
S/AS01, indicates that malaria vaccine R&D is moving into a new phase. Field trials of …
Saponins from Quillaja saponaria and Quillaja brasiliensis: Particular Chemical Characteristics and Biological Activities
Quillaja saponaria Molina represents the main source of saponins for industrial applications.
Q. saponaria triterpenoids have been studied for more than four decades and their …
Q. saponaria triterpenoids have been studied for more than four decades and their …
Extreme polymorphism in a vaccine antigen and risk of clinical malaria: implications for vaccine development
SL Takala, D Coulibaly, MA Thera… - Science translational …, 2009 - science.org
Vaccines directed against the blood stages of Plasmodium falciparum malaria are intended
to prevent the parasite from invading and replicating within host cells. No blood-stage …
to prevent the parasite from invading and replicating within host cells. No blood-stage …
Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1) administered in adjuvant system AS01B or AS02A
MD Spring, JF Cummings, CF Ockenhouse, S Dutta… - PloS one, 2009 - journals.plos.org
Background This Phase 1/2a study evaluated the safety, immunogenicity, and efficacy of an
experimental malaria vaccine comprised of the recombinant Plasmodium falciparum protein …
experimental malaria vaccine comprised of the recombinant Plasmodium falciparum protein …
A randomized controlled phase 2 trial of the blood stage AMA1-C1/Alhydrogel malaria vaccine in children in Mali
I Sagara, A Dicko, RD Ellis, MP Fay, SI Diawara… - Vaccine, 2009 - Elsevier
A double blind, randomized, controlled Phase 2 clinical trial was conducted to assess the
safety, immunogenicity, and biologic impact of the vaccine candidate Apical Membrane …
safety, immunogenicity, and biologic impact of the vaccine candidate Apical Membrane …
Demonstration of the Blood-Stage Plasmodium falciparum Controlled Human Malaria Infection Model to Assess Efficacy of the P. falciparum Apical Membrane …
RO Payne, KH Milne, SC Elias… - The Journal of …, 2016 - academic.oup.com
Background. Models of controlled human malaria infection (CHMI) initiated by mosquito bite
have been widely used to assess efficacy of preerythrocytic vaccine candidates in small …
have been widely used to assess efficacy of preerythrocytic vaccine candidates in small …