Pharmacokinetics (PK) is the study of the absorption, distribution, metabolism, and excretion
(ADME) processes of a drug. Understanding PK properties is essential for drug development …

Drug transporters are considered to be determinants of drug disposition and effects/toxicities
by affecting the absorption, distribution, and excretion of drugs. Drug transporters are …

Introduction: Organic cation transporters collectively called OCTs belong to three gene
families (SLC22A1 OCT1, SLC22A2 OCT2, SLC22A3 OCT3, SLC22A4 OCTN1, SLC22A5 …

Recent advances in the identification and characterization of renal drug transporters and
drug‐metabolizing enzymes has led to greater understanding of their roles in drug and …

Pharmacokinetic drug–drug interactions (DDIs) occur when a drug alters the absorption,
transport, distribution, metabolism or excretion of a co-administered agent. The occurrence …

Abstract Introduction Coproporphyrin (CP) I and III have recently been proposed as
endogenous clinical biomarkers to predict organic anion-transporting polypeptide 1B …

Transporters govern the access of molecules to cells or their exit from cells, thereby
controlling the overall distribution of drugs to their intracellular site of action. Clinically …

The organic anion transporters (OATs) and organic anion–transporting polypeptides
(OATPs) belong to the solute carrier (SLC) transporter superfamily and play important roles …

The kidney plays a vital role in maintaining systemic homeostasis. Active tubular secretion
and reabsorption, which are mainly mediated by transporters, is an efficient mechanism for …

Anaplastic lymphoma kinase (ALK) inhibitors are important treatment options for non-small-
cell lung cancer (NSCLC), associated with ALK gene rearrangement. Patients with ALK …