Activation of PPAR gamma receptors reduces levodopa-induced dyskinesias in 6-OHDA-lesioned rats

AA Martinez, MG Morgese, A Pisanu, T Macheda… - Neurobiology of …, 2015 - Elsevier
Long-term administration of l-3, 4-dihydroxyphenylalanine (levodopa), the mainstay
treatment for Parkinson's disease (PD), is accompanied by fluctuations in its duration of …

[HTML][HTML] PPAR-γ agonist GW1929 but not antagonist GW9662 reduces TBBPA-induced neurotoxicity in primary neocortical cells

AK Wojtowicz, KA Szychowski, M Kajta - Neurotoxicity Research, 2014 - Springer
Abstract Tetrabromobisphenol A (2, 2-bis (4-hydroxy-3, 5-dibromophenyl) propane; TBBPA)
is a widely used brominated flame retardant. TBBPA induces neuronal damage, but the …

Modulating microglia activity with PPAR-γ agonists: a promising therapy for Parkinson's disease?

AR Carta, A Pisanu - Neurotoxicity research, 2013 - Springer
A dysregulated response of the neuroimmune system is a main contributor to the
progression of neurodegeneration in Parkinson's disease (PD). Recent findings suggest that …

NMDA receptor involvement in antidepressant-like effect of pioglitazone in the forced swimming test in mice

M Salehi-Sadaghiani, M Javadi-Paydar… - …, 2012 - Springer
Rationale Previously, we showed that pioglitazone exerts its antidepressant-like effect
through peroxisome proliferator-activated receptor gamma receptors and demonstrated the …

Effects of xenoestrogens on the differentiation of behaviorally-relevant neural circuits

GC Panzica, C Viglietti-Panzica, E Mura… - Frontiers in …, 2007 - Elsevier
It has become increasingly clear that environmental chemicals have the capability of
impacting endocrine function. Moreover, these endocrine disrupting chemicals (EDCs) have …

Emerging roles of peroxisome proliferator-activated receptors (PPARs) in the regulation of neural stem cells proliferation and differentiation

AM Cimini, MP Cerù - Stem cell reviews, 2008 - Springer
The molecular mechanisms controlling the specification of neural cell fates have been the
focus of intense research in recent years. Neural precursor cells (NPCs) sequentially …

[HTML][HTML] Anti-kindling effect of bezafibrate, a peroxisome proliferator-activated receptors alpha agonist, in pentylenetetrazole induced kindling seizure model

L Saha, S Bhandari, A Bhatia, D Banerjee… - Journal of Epilepsy …, 2014 - ncbi.nlm.nih.gov
Background and Purpose: Studies in the animals suggested that Peroxisome proliferators
activated receptors (PPARs) may be involved in seizure control and selective agonists of …

Neuronal expression of peroxisome proliferator-activated receptor-gamma (PPARγ) and 15d-prostaglandin J2—Mediated protection of brain after experimental …

Z Ou, X Zhao, LA Labiche, R Strong, JC Grotta… - Brain research, 2006 - Elsevier
Existing experimental evidence suggests that PPARγ may play a beneficial role in
neuroprotection from various brain pathologies. Here we found that focal cerebral ischemia …

[HTML][HTML] Megalin/LRP2 expression is induced by peroxisome proliferator-activated receptor-alpha and-gamma: implications for PPARs' roles in renal function

F Cabezas, J Lagos, C Céspedes, CP Vio… - PloS one, 2011 - journals.plos.org
Background Megalin is a large endocytic receptor with relevant functions during
development and adult life. It is expressed at the apical surface of several epithelial cell …

Expression of E‐FABP in PC12 cells increases neurite extension during differentiation: involvement of n‐3 and n‐6 fatty acids

JW Liu, FG Almaguel, L Bu, DD De Leon… - Journal of …, 2008 - Wiley Online Library
Epidermal fatty acid‐binding protein (E‐FABP), a member of the family of FABPs, exhibits a
robust expression in neurons during axonal growth in development and in nerve …