Inflammation is a known precipitator of neuronal death after cerebral ischemia. The
mechanisms that promote or curtail the start and spread of inflammation in brain are still …

Oxidative stress has been found to be associated with the progression of neurodegenerative
diseases such as Alzheimer's, Parkinson's, Lou Gehrig's, etc. In the recent years, cerium …

Up‐regulation of cyclooxygenase (COX)‐2 exacerbates neuronal injury after cerebral
ischemia and contributes to neuronal cell death. The present study clarifies the function of …

Signalling lipids are known to control a wide array of cellular processes, including cell
proliferation, apoptosis, migration, and energy metabolism. Fatty acids and their derivatives …

Peroxisome proliferator-activated receptors (PPARs) have long been known as mediators of
several physiological functions, among which the best characterized are lipid metabolism …

Docosahexaenoic acid (DHA) is an omega-3 (ω-3) long-chain polyunsaturated fatty acid
(LCPUFA) relevant for brain function. It has largely been explored as a potential candidate to …

Inhibitors of fatty acid amide hydrolase (FAAH) increase endogenous levels of anandamide
(a cannabinoid CB1-receptor ligand) and oleoylethanolamide and palmitoylethanolamide …

Despite the clear roles played by peroxisome proliferators-activated receptor α (PPAR-α) in
lipid metabolism, inflammation and feeding, the effects of its activation in the central nervous …

The relationship between diabetes mellitus and Parkinson's disease has been described in
several epidemiological studies over the 1960s to date. Molecular studies have shown the …

Glycogen synthase kinase-3β (GSK-3β) is an enzyme that phosphorylates glycogen
synthase, thereby inhibiting glycogen synthesis. Besides this role, it is now believed that this …