PPARα signaling: A candidate target in psychiatric disorder management

S Scheggi, G Pinna, G Braccagni, MG De Montis… - Biomolecules, 2022 - mdpi.com
Peroxisome proliferator-activator receptors (PPARs) regulate lipid and glucose metabolism,
control inflammatory processes, and modulate several brain functions. Three PPAR isoforms …

Roles of PPAR transcription factors in the energetic metabolic switch occurring during adult neurogenesis

E Di Giacomo, E Benedetti, L Cristiano, A Antonosante… - Cell Cycle, 2017 - Taylor & Francis
PPARs are a class of ligand-activated transcription factors belonging to the superfamily of
receptors for steroid and thyroid hormones, retinoids and vitamin D that control the …

Endocannabinoids, adipose tissue and lipid metabolism

C Pagano, M Rossato, R Vettor - Journal of …, 2008 - Wiley Online Library
Endoannabinoids regulate energy balance by modulating hypothalamic circuits controlling
food intake and energy expenditure. However, convincing evidence has accumulated …

Bezafibrate upregulates mitochondrial biogenesis and influence neural differentiation of human-induced pluripotent stem cells

J Augustyniak, J Lenart, P Gaj, M Kolanowska… - Molecular …, 2019 - Springer
Bezafibrate (BZ) regulates mitochondrial biogenesis by activation of PPAR's receptors and
enhancing the level of PGC-1α coactivator. In this report, we investigated the effect of BZ on …

Effects of the fatty acid amide hydrolase inhibitor URB597 on the sleep-wake cycle, c-Fos expression and dopamine levels of the rat

E Murillo-Rodríguez, E Vázquez… - European journal of …, 2007 - Elsevier
Our group has described previously that the endogenous cannabinoid anandamide induces
sleep. The hydrolysis of this lipid involves the activity of the fatty acid amide hydrolase …

Peroxisome proliferator‐activated receptor‐alpha is required for the neurotrophic effect of oleic acid in neurons

A Bento‐Abreu, A Tabernero… - Journal of …, 2007 - Wiley Online Library
Oleic acid synthesized by astrocytes behaves as a neurotrophic factor for neurons, up‐
regulating the molecular markers of axonal and dendritic outgrowth, growth‐associated …

Do PPAR‐Gamma Agonists Have a Future in Parkinson′ s Disease Therapy?

AR Carta, A Pisanu, E Carboni - Parkinson's disease, 2011 - Wiley Online Library
Thiazolidinediones (TZDs) are peroxisome proliferator‐activated receptor (PPAR)‐γ
agonists commonly used as insulin‐sensitizing drugs for the treatment of type 2 diabetes. In …

The identification of peroxisome proliferator‐activated receptor alpha‐independent effects of oleoylethanolamide on intestinal transit in mice

NL Cluny, CM Keenan, B Lutz… - …, 2009 - Wiley Online Library
Oleoylethanolamide (OEA) is an endogenous lipid produced in the intestine that mediates
satiety by activation of peroxisome proliferator‐activated receptor alpha (PPARα). OEA …

Acute neuroprotection by pioglitazone after mild brain ischemia without effect on long-term outcome

S Ji, G Kronenberg, M Balkaya, K Färber, K Gertz… - Experimental …, 2009 - Elsevier
Peroxisome proliferator-activated receptor-gamma (PPAR-γ) agonists (thiazolidinediones)
have anti-inflammatory effects and improve endothelium function. Here, we analyzed the …

Endothelium-dependent vasodilator effects of peroxisome proliferator-activated receptor β agonists via the phosphatidyl-inositol-3 kinase-Akt pathway

R Jimenez, M Sanchez, MJ Zarzuelo, M Romero… - … of Pharmacology and …, 2010 - ASPET
Peroxisome proliferator-activated receptor β/δ (PPAR-β) is a ligand-activated transcription
factor belonging to the nuclear hormone receptor superfamily that regulates the transcription …