Therapeutic prospects of PPARs in psychiatric disorders: a comprehensive review

B Rolland, J Deguil, R Jardri, O Cottencin… - Current drug …, 2013 - ingentaconnect.com
Peroxisome Proliferator-Activated Receptors (PPARs) are a family of nuclear receptors
whose activation modulates the gene expression that underlies both the glucid-lipid and the …

Dual PPARα/γ agonist aleglitazar confers stroke protection in a model of mild focal brain ischemia in mice

V Boujon, R Uhlemann, S Wegner, MB Wright… - Journal of Molecular …, 2019 - Springer
Peroxisome proliferator-activated receptors (PPARs) control the expression of genes
involved in glucose homeostasis, lipid metabolism, inflammation, and cell differentiation …

[HTML][HTML] Cell migration is impaired in XPA‐deficient cells

S Takeuchi, T Fukumoto, C Takemori, N Saito… - FASEB …, 2023 - ncbi.nlm.nih.gov
Xeroderma pigmentosum (XP) is a hereditary disorder characterized by photosensitivity,
predisposition to skin cancers, and neurological abnormalities including microcephaly and …

PPARγ regulates the mitochondrial dysfunction in human neural stem cells with tumor necrosis factor alpha

MC Chiang, YC Cheng, KH Lin, CH Yen - Neuroscience, 2013 - Elsevier
Peroxisome proliferator-activated receptor gamma (PPARγ) belongs to a family of ligand-
activated transcription factors, and its ligands are known to control many physiological and …

Targeting the peroxisome proliferator-activated receptors (PPARs) in spinal cord injury

E Esposito, S Cuzzocrea - Expert opinion on therapeutic targets, 2011 - Taylor & Francis
Introduction: Traumatic spinal cord injury (SCI) causes severe and permanent functional
deficits, due to the primary mechanical insult, followed by secondary tissue degeneration …

PPARβ agonists trigger neuronal differentiation in the human neuroblastoma cell line SH‐SY5Y

S Di Loreto, B D'angelo, MA D'amico… - Journal of cellular …, 2007 - Wiley Online Library
Neuroblastomas are pediatric tumors originating from immature neuroblasts in the
developing peripheral nervous system. Differentiation therapies could help lowering the …

Simvastatin exerts antidepressant-like activity in mouse forced swimming test: Role of NO-cGMP-KATP channels pathway and PPAR-gamma receptors

R Naserzadeh, N Abad, B Ghorbanzadeh… - Pharmacology …, 2019 - Elsevier
Simvastatin, one of the lipophilic statins, has been shown to be effective in reducing
depression in rodents. The present study aimed to investigate the potential antidepressant …

In vivo pharmacology of endocannabinoids and their metabolic inhibitors: therapeutic implications in Parkinson's disease and abuse liability

A Giuffrida, LR McMahon - Prostaglandins & other lipid mediators, 2010 - Elsevier
This review focuses on the behavioral pharmacology of endogenous cannabinoids
(endocannabinoids) and indirect-acting cannabinoid agonists that elevate endocannabinoid …

The role of microRNA in neuronal inflammation and survival in the post ischemic brain: a review

WA Li, A Efendizade, Y Ding - Neurological research, 2023 - Taylor & Francis
Each year, more than 790 000 people in the United States suffer from a stroke. Although
progress has been made in diagnosis and treatment of ischemic stroke (IS), new therapeutic …

RAR/RXR and PPAR/RXR signaling in spinal cord injury

S Van Neerven, J Mey - PPAR research, 2007 - Wiley Online Library
The retinoid acid receptors (RAR) and peroxisome proliferator‐activated receptors (PPAR)
have been implicated in the regulation of inflammatory reactions. Both receptor families …