Kidney stones (also known as urinary stones or nephrolithiasis) are highly prevalent,
affecting approximately 10% of adults worldwide, and the incidence of stone disease is …

Claudins are tight junction membrane proteins that are expressed in epithelia and
endothelia and form paracellular barriers and pores that determine tight junction …

Kidney stone disease (nephrolithiasis) is a common problem that can be associated with
alterations in urinary solute composition including hypercalciuria. Studies suggest that the …

The tight junction forms a barrier against unlimited paracellular passage but some of the
tight junction proteins just do the opposite, they form extracellular channels zigzagging …

The direct nucleic acid repair dioxygenase FTO is an enzyme that demethylates N 6-
methyladenosine (m6A) residues in mRNA in vitro and inside cells. FTO is the first RNA …

Context: The pathogenetic mechanisms of kidney stone formation are complex and involve
both metabolic and environmental risk factors. Over the past decade, major advances have …

The physiological process of biomineralization is complex and deviation from it leads to a
variety of diseases. Progress in the past 10 years has enhanced understanding of the …

The paracellular claudin channel of the thick ascending limb (TAL) of Henle is critical for
Ca++ reabsorption in the kidney. Genome‐wide association studies (GWASs) have …

The major risk factor for kidney stone disease is idiopathic hypercalciuria. Recent evidence
implicates a role for defective calcium reabsorption in the renal proximal tubule. We …

Objective To test the hypothesis that there is an increase in the incidence of childhood
nephrolithiasis in the state of South Carolina. Study design We analyzed demographic data …