Recent reports show an increased occurrence of kidney stone disease worldwide. To further
evaluate and quantify this observation, we examined recent trends in the incidence of kidney …

The thick ascending limb occupies a central anatomic and functional position in human
renal physiology, with critical roles in the defense of the extracellular fluid volume, the …

BACKGROUND & AIMS: In the small intestine, the paracellular transport of Na+ is thought to
be critical for luminal Na+-homeostasis and the transcellular absorption of nutrients by Na+ …

The ability to monitor changes in the ionic composition of the extracellular environment is a
crucial feature that has evolved in all living organisms. The cloning and characterization of …

Kidney stone disease is a complex disorder with a strong genetic component. We conducted
a genome-wide association study of 28.3 million sequence variants detected through whole …

Urolithiasis, a complex multifactorial disease, results from interactions between
environmental and genetic factors. Epidemiological studies have shown the association of …

Nephrolithiasis remains a formidable health problem in the United States and worldwide. A
very important but underaddressed area in nephrolithiasis is the accompanying bone …

Claudins are tight-junction membrane proteins that function as both pores and barriers in the
paracellular pathway in epithelial cells. In the kidney, claudins determine the permeability …

Aiming to identify novel genetic variants and to confirm previously identified genetic variants
associated with bone mineral density (BMD), we conducted a three-stage genome-wide …

Kidney stone disease (nephrolithiasis) is a major clinical and economic health burden with a
heritability of~ 45–60%. We present genome-wide association studies in British and …