The role of the kidney in calcium homeostasis has been reshaped from a classic view in
which the kidney was regulated by systemic calcitropic hormones such as vitamin D3 or …

Claudins are tight junction membrane proteins that regulate paracellular permeability of
renal epithelia to small ions, solutes, and water. Claudins interact within the cell membrane …

Kidney stones are a prevalent clinical condition imposing a large economic burden on the
healthcare system. Hypercalciuria remains the major risk factor for development of a Ca2+ …

Renal stone disease is a frequent condition, causing a huge burden on health care systems
globally. Calcium-based calculi account for around 75% of renal stone disease and the …

A prerequisite of epithelial transport is a paracellular barrier function, which seals the tissue
against an uncontrolled leak flux. Moreover, selective paracellular permeability has been …

Central to the maintenance of calcium homeostasis is the regulated reabsorption of calcium
along the nephron. To this end, parathyroid hormone (PTH) is released from the parathyroid …

Background While genome-wide associations studies (GWAS) have successfully elucidated
the genetic architecture of complex human traits and diseases, understanding mechanisms …

Kidney stone disease (KSD) is a complex disorder with high heritability and prevalence. We
performed a large genome-wide association study (GWAS) meta-analysis for KSD to date …

In the kidney, tight junction proteins contribute to segment specific selectivity and
permeability of paracellular ion transport. In the thick ascending limb (TAL) of Henle's loop …

Context: The primary goals of genome-wide association studies (GWAS) are to discover new
molecular and biological pathways involved in the regulation of bone metabolism that can …