Background: Calcium nephrolithiasis is a multifactorial disease with a polygenic milieu.
Association studies identified genetic polymorphisms potentially implicated in the …

Parathyroid hormone (PTH) is a primary calcium regulatory hormone. Elevated serum PTH
concentrations in primary and secondary hyperparathyroidism have been associated with …

The effect of nutritional vitamin D use in stone formers is still not clear. As vitamin D
deficiency is highly prevalent among stone formers, future prospective studies are needed to …

OBJECTIVE: To identify correlates of kidney stone disease in white and African American
men and women in a population-based longitudinal study starting in four US communities …

The kidney has a major role in extracellular calcium homeostasis. Multiple genetic linkage
and association studies identified three tight junction genes from the kidney—claudin-14 …

Context Urolithiasis has a high prevalence and recurrence rate. Prevention is key to patient
management, but risk stratification is challenging. In particular, genetic predisposition for …

Purpose Accumulating evidence implicates parathyroid hormone (PTH) in the development
of osteoporosis. However, the causal effect of PTH on bone mineral density (BMD) remains …

Calcium nephrolithiasis is one of the most prevalent uronephrologic disorders in the western
countries. Studies in families and twins evidenced a genetic predisposition to calcium …

The majority of calcium filtered by the glomerulus is reabsorbed along the nephron. Most is
reabsorbed from the proximal tubule (> 60%) via a paracellular pathway composed of the …

The pathophysiology of chronic kidney disease–mineral and bone disorder accounts for an
inverse relationship between bone mineralization and vascular calcification in progressive …