Kidney stone, one of the oldest known diseases, has plagued humans for centuries,
consistently imposing a heavy burden on patients and healthcare systems worldwide due to …

Kidney stone disease is a common disorder in Western countries that is associated with
significant suffering, morbidity, and cost for the healthcare system. Numerous studies have …

Kidney stone disease comprising nephrolithiasis and nephrocalcinosis is a clinical
syndrome of increasing prevalence with remarkable heterogeneity. Stone composition, age …

Background Treatment with the aminoglycoside antibiotic gentamicin can be associated with
severe adverse effects, including renal Ca 2+ wasting. The underlying mechanism is …

The prevalence of urolithiasis in humans is increasing worldwide; however, non-surgical
treatment and prevention options remain limited despite decades of investigation. Most …

Background The clinical presentation of the inflammatory bowel diseases (IBD) is extremely
heterogenous and is characterized by various extraintestinal manifestations and …

The kidney medulla is a specialized region with important homeostatic functions. It has been
implicated in genetic and developmental disorders along with ischemic and drug-induced …

The primary function of the gastrointestinal tract is to digest and absorb nutrients. To
accomplish this, it must maintain a barrier between the luminal environment, technically a …

Background A family history of urolithiasis is associated with a more than doubling of
urolithiasis risk, and a twin study estimating 56% heritability of the condition suggests a …

Background Elevated serum 1, 25-dihydroxyvitamin D (1, 25 (OH) 2D) concentrations have
been reported among cohorts of recurrent calcium (Ca) kidney stone-formers and implicated …