The thick ascending limb of Henle's loop (TAL) drives an important part of the reabsorption
of divalent cations. This reabsorption occurs via the paracellular pathway formed by the tight …

Our meta-analysis demonstrates that people with nephrolithiasis have decreased bone
mineral density, an increased odds of osteoporosis, and potentially an elevated risk of …

Background Linking genetic risk loci identified by genome-wide association studies (GWAS)
to their causal genes remains a major challenge. Disease-associated genetic variants are …

The thick ascending limb plays a central role in human kidney physiology, participating in
sodium reabsorption, urine concentrating mechanisms, calcium and magnesium …

Claudins and nephrolithiasis : Current Opinion in Nephrology and Hypertension Claudins and
nephrolithiasis : Current Opinion in Nephrology and Hypertension Log in or Register Subscribe to …

Kidney stone disease (KSD) is a prevalent condition associated with high morbidity, frequent
recurrence, and progression to chronic kidney disease (CKD). The etiology is multifactorial …

Paracellular transport in the kidney is mediated by a family of proteins located in the tight
junctions called claudins which confers its ionic selectivity. Claudin-2 is highly expressed in …

Idiopathic osteoporosis and nephrolithiasis are formidable health problems showing a
progressive increase in their incidence and prevalence in the last decades. These temporal …

Kidney stones composed predominantly (50% or more) of calcium phosphate constitute up
to 10% of all stones and 15%–20% of calcium stones, 80% of which are composed of …

The greatest risk factor for kidney stones is hypercalciuria, the etiology of which is largely
unknown. A recent genome‐wide association study (GWAS) linked hypercalciuria and …