Molnupiravir: first approval

YY Syed - Drugs, 2022 - Springer
Molnupiravir (Lagevrio®) is an orally-administered antiviral prodrug that inhibits replication
of RNA viruses through viral error induction. It is being developed by Merck and Ridgeback …

Molnupiravir: A lethal mutagenic drug against rapidly mutating severe acute respiratory syndrome coronavirus 2—A narrative review

S Masyeni, M Iqhrammullah… - Journal of Medical …, 2022 - Wiley Online Library
Broad‐spectrum antiviral agents targeting viral RNA‐dependent RNA polymerase (RdRp)
are expected to be a key therapeutic strategy in the ongoing coronavirus disease 2019 …

[HTML][HTML] Pharmacological treatment of COVID-19: an opinion paper

A García-Lledó, J Gómez-Pavón… - Revista Española de …, 2022 - ncbi.nlm.nih.gov
The precocity and efficacy of the vaccines developed so far against COVID-19 has been the
most significant and saving advance against the pandemic. The development of vaccines …

[HTML][HTML] Comparative molecular docking and simulation analysis of molnupiravir and remdesivir with SARS-CoV-2 RNA dependent RNA polymerase (RdRp)

SM Patil, KR Maruthi, SN Bajpe, VM Vyshali… - …, 2021 - ncbi.nlm.nih.gov
Abstract Treatment of SARS-CoV-2 targeting its RNA dependent RNA polymerase (RdRp) is
of current interest. Remdesivir has been approved for the treatment of COVID-19 around the …

Metallodrug Profiling against SARS‐CoV‐2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain‐like Protease PLpro

M Gil‐Moles, S Türck, U Basu… - … A European Journal, 2021 - Wiley Online Library
The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
has called for an urgent need for dedicated antiviral therapeutics. Metal complexes are …

Human genetic risk of treatment with antiviral nucleoside analog drugs that induce lethal mutagenesis: the special case of molnupiravir

MD Waters, S Warren, C Hughes… - Environmental and …, 2022 - Wiley Online Library
This review considers antiviral nucleoside analog (NA) drugs, including ribavirin, favipiravir,
and molnupiravir, which induce genome error catastrophe in SARS‐CoV or SARS‐CoV‐2 …

[HTML][HTML] A critical analysis of SARS-CoV-2 (COVID-19) complexities, emerging variants, and therapeutic interventions and vaccination strategies

CX Li, S Noreen, LX Zhang, M Saeed, PF Wu… - Biomedicine & …, 2022 - Elsevier
Coronavirus is a family of viruses that can cause diseases such as the common cold, severe
acute respiratory syndrome (SARS), and Middle East respiratory syndrome (MERS). The …

Development and validation of molnupiravir assessment in bulk powder and pharmaceutical formulation by the RP-HPLC-UV method

AM Annadi, NM El Zahar, NEDA Abdel-Sattar… - RSC …, 2022 - pubs.rsc.org
An accurate, sensitive and selective RP-HPLC-UV method has been established for the
estimation of Molnupiravir (MOL) in pure bulk powder and pharmaceutical formulation …

[HTML][HTML] The pill of recovery; Molnupiravir for treatment of COVID-19 patients; a systematic review

L Kamal, A Ramadan, S Farraj, L Bahig… - Saudi Pharmaceutical …, 2022 - Elsevier
Background Throughout the time of the global pandemic of SARS-CoV-2 virus, there has
been a compelling necessity for the development of effective antiviral agents and …

[HTML][HTML] Evaluation of molnupiravir (EIDD-2801) efficacy against SARS-CoV-2 in the rhesus macaque model

DM Johnson, T Brasel, S Massey, T Garron, M Grimes… - Antiviral research, 2023 - Elsevier
Abstract Molnupiravir (EIDD-2801) is a prodrug of a ribonucleoside analogue that is
currently being used under a US FDA emergency use authorization for the treatment of mild …