HIV-1-infected cells that persist despite antiretroviral therapy (ART) are frequently
considered" transcriptionally silent," but active viral gene expression may occur in some …

The origin story and emergence of molecular biology is muddled. The early triumphs in
bacterial genetics and the complexity of animal and plant genomes complicate an intricate …

Repetitive DNA is a major organizational component of eukaryotic genomes, being
intrinsically related with their architecture and evolution. Tandemly repeated satellite DNAs …

Even though the recent advances in 'complete genomics' revealed the previously
inaccessible genomic regions, analysis of variations in centromeres and other extra-long …

Centromeric variation has been linked to cancer and infertility, but centromere sequences
contain multiple tandem repeats and can only be assembled manually from long error-prone …

Alzheimer's disease (AD) is characterized by the presence of β-amyloid plaques (Aβ) and
neurofibrillary tangles (NFTs) in the brain. The prevalence of the disease is increasing and is …

Intrinsic genomic features of individual chromosomes can contribute to chromosome‐
specific aneuploidy. Centromeres are key elements for the maintenance of chromosome …

Mitotic entry correlates with the condensation of the chromosomes, changes in histone
modifications, exclusion of transcription factors from DNA, and the broad downregulation of …

A substantial portion of the primate genome is composed of non-coding regions, so-called
“dark matter”, which includes an abundance of tandemly repeated sequences called satellite …

Since their discovery more than 60 years ago, satellite repeats are still one of the most
enigmatic parts of eukaryotic genomes. Being non-coding DNA, satellites were earlier …