Stroke remains a leading cause of death and disability, with limited therapeutic options and
suboptimal tools for diagnosis and prognosis. High throughput technologies such as …

Insulin is a key hormone regulating metabolism. Insulin binding to cell surface insulin
receptors engages many signaling intermediates operating in parallel and in series to …

Icariin (ICA), an active flavonoid extracted from Chinese medicinal herb Epimedii, has been
reported to exhibit many pharmacological effects including alleviating brain injury. However …

Protein disulfide isomerase (PDI) participates in the pathogenesis of numerous diseases.
Increasing evidence indicates that intravascular cell-derived PDI plays an important role in …

Insulin resistance can occur when the body is unable to respond to insulin even in excess. In
the brain, insulin manages glucose metabolism in regions such as the hippocampus and …

This experiment was conducted to evaluate whether pretreatment with fenofibrate could
mitigate acute lung injury (ALI) in a mice model of intestinal ischemia/reperfusion (I/R). Male …

Background Fenofibrate, a PPAR-α activator, has shown promising results as a
neuroprotective therapy, with proposed anti-inflammatory and anti-oxidant effects. However …

Highlights•Network pharmacology, which relies on omics, is the next paradigm in drug
discovery.•Proteomics is a valuable tool in all stages of the drug discovery …

Torsion of the spermatic cord is a common urological emergency among infants and
adolescents that can lead to testicular necrosis and infertility. We investigated the effect of …

Ischemic stroke (IS) is the most common type of stroke and is characterized by high rates of
mortality and long-term injury. The prediction and early diagnosis of IS are therefore crucial …