Problems of pathogenesis and pathogenetic therapy of COVID-19 from the perspective of the general theory of pathological systems (general pathological processes)
E Gusev, A Sarapultsev, D Hu… - International journal of …, 2021 - mdpi.com
The COVID-19 pandemic examines not only the state of actual health care but also the state
of fundamental medicine in various countries. Pro-inflammatory processes extend far …
of fundamental medicine in various countries. Pro-inflammatory processes extend far …
SARS-CoV-2 crosses the blood–brain barrier accompanied with basement membrane disruption without tight junctions alteration
L Zhang, L Zhou, L Bao, J Liu, H Zhu, Q Lv… - Signal transduction and …, 2021 - nature.com
SARS-CoV-2 has been reported to show a capacity for invading the brains of humans and
model animals. However, it remains unclear whether and how SARS-CoV-2 crosses the …
model animals. However, it remains unclear whether and how SARS-CoV-2 crosses the …
Platelets in viral infections–brave soldiers or Trojan horses
WC Schrottmaier, A Schmuckenschlager… - Frontiers in …, 2022 - frontiersin.org
Viral infections are often associated with platelet activation and haemostatic complications.
In line, low platelet counts represent a hallmark for poor prognosis in many infectious …
In line, low platelet counts represent a hallmark for poor prognosis in many infectious …
SARS-CoV-2 spike protein induces degradation of junctional proteins that maintain endothelial barrier integrity
S Raghavan, DB Kenchappa, MD Leo - Frontiers in cardiovascular …, 2021 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses the Angiotensin
converting enzyme 2 (ACE2) receptor present on the cell surface to enter cells. Angiotensin …
converting enzyme 2 (ACE2) receptor present on the cell surface to enter cells. Angiotensin …
Endothelial cells are not productively infected by SARS‐CoV‐2
L Schimmel, KY Chew, CJ Stocks… - Clinical & …, 2021 - Wiley Online Library
Objectives Thrombotic and microvascular complications are frequently seen in deceased
COVID‐19 patients. However, whether this is caused by direct viral infection of the …
COVID‐19 patients. However, whether this is caused by direct viral infection of the …
SARS-CoV-2 Infects Human ACE2-Negative Endothelial Cells through an αvβ3 Integrin-Mediated Endocytosis Even in the Presence of Vaccine-Elicited Neutralizing …
A Bugatti, F Filippini, M Bardelli, A Zani, P Chiodelli… - Viruses, 2022 - mdpi.com
Integrins represent a gateway of entry for many viruses and the Arg-Gly-Asp (RGD) motif is
the smallest sequence necessary for proteins to bind integrins. All Severe Acute Respiratory …
the smallest sequence necessary for proteins to bind integrins. All Severe Acute Respiratory …
Interferon-alpha or-beta facilitates SARS-CoV-2 pulmonary vascular infection by inducing ACE2
Severe viral pneumonia caused by the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is characterized by a hyperinflammatory state typified by elevated circulating …
(SARS-CoV-2) is characterized by a hyperinflammatory state typified by elevated circulating …
Nitric oxide-mediated cutaneous microvascular function is not altered in young adults following mild-to-moderate SARS CoV-2 infection
Vascular dysfunction has been reported in adults who have recovered from COVID-19. To
date, no studies have investigated the underlying mechanisms of persistent COVID-19 …
date, no studies have investigated the underlying mechanisms of persistent COVID-19 …
Circulatory exosomes from COVID-19 patients trigger NLRP3 inflammasome in endothelial cells
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces
inflammatory response, cytokine storm, venous thromboembolism, coagulopathy, and …
inflammatory response, cytokine storm, venous thromboembolism, coagulopathy, and …
The kidney in hantavirus infection—epidemiology, virology, pathophysiology, clinical presentation, diagnosis and management
FC Koehler, V Di Cristanziano, MR Späth… - Clinical kidney …, 2022 - academic.oup.com
Hantavirus-induced diseases are emerging zoonoses with endemic appearances and
frequent outbreaks in different parts of the world. In humans, hantaviral pathology is …
frequent outbreaks in different parts of the world. In humans, hantaviral pathology is …