Upon fertilization, the mammalian embryo must switch from dependence on maternal
transcripts to transcribing its own genome, and in mice this involves the transient up …

The molecular mechanism controlling the zygotic genome activation (ZGA) in mammals
remains poorly understood. The 2-cell (2C)-like cells spontaneously emerging from cultures …

Human endogenous retroviruses (HERVs) represent∼ 8% of human genome, deriving from
exogenous retroviral infections of germ line cells occurred millions of years ago and being …

Joint profiling of transcriptome and chromatin accessibility within single cells allows for the
deconstruction of the complex relationship between transcriptional states and upstream …

Our efforts to understand the developmental origins of birth defects and disease have
primarily focused on maternal exposures and intrauterine stressors. Recently, research into …

Whilst a disease-modifying treatment for Facioscapulohumeral muscular dystrophy (FSHD)
does not exist currently, recent advances in complex molecular pathophysiology studies of …

Known as a histone H3K9 methyltransferase, SETDB1 is essential for embryonic
development and pluripotent inner cell mass (ICM) establishment. However, its function in …

Zygotic genome activation (ZGA) denotes the initiation of gene expression after fertilization.
It is part of the complex oocyte-to-embryo transition (OET) in which a highly specialized cell …

Abstract CIC-DUX4 sarcoma (CDS) is a highly aggressive and metastatic small round type
of predominantly pediatric sarcoma driven by a fusion oncoprotein comprising the …

Lactate was recently found to mediate histone lysine lactylation and facilitate polarization of
M1 macrophages, indicating its role in metabolic regulation of gene expression. During …