Cultured brain cells are capable of generating many molecules associated with
inflammatory and immune functions. They constitute the endogenous immune response …

Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disease. Due to
its long clinical course and lack of an effective treatment, AD has become a major public …

This retrospective cohort study is to investigate the association between herpes simplex
virus (HSV) infections and dementia, and the effects of anti-herpetic medications on the risk …

Apolipoprotein E (APOE) dependent lifetime risks (LTRs) for Alzheimer Disease (AD) are
currently not accurately known and odds ratios alone are insufficient to assess these risks …

Patients with Alzheimer's disease (AD) have elevations of fasting plasma insulin that are
hypothesized to be associated with disrupted brain insulin metabolism. We examined paired …

Background Soluble beta-amyloid (Aβ) can be cleared from the brain through various
mechanisms including enzymatic degradation, glial cell phagocytosis, transport across the …

Background Apolipoprotein E (APOE) ε4 is the single most important genetic risk factor for
cognitive impairment and Alzheimer disease (AD), while lifestyle factors such as smoking …

Population Genetics and Microevolutionary Theory Explore the fundamentals of the
biological implications of population genetic theory In the newly revised Second Edition of …

Apolipoprotein E (APOE) is a lipid-transport protein abundantly expressed in most neurons
in the central nervous system. APOE-dependent alterations of the endocytic pathway can …

The prevalence of dementia in subjects 65 years and older in North America is
approximately 6%–10%, with Alzheimer's disease (AD) accounting for two-thirds of these …